Evidence map›Paper›PMID 41633601›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026

[Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies].

J Chu, P Li, J Tian, D Fu, L Guo, R Sun, Y Li

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

J ChuDepartment of Rheumatology and Immunology, General Hospital of Northern Theater Command, Shenyang 110001, China.
P LiDepartment of Rheumatology and Immunology, General Hospital of Northern Theater Command, Shenyang 110001, China.
J TianDepartment of Orthopedics, General Hospital of Northern Theater Command, Shenyang 110001, China.
D FuDepartment of Rheumatology and Immunology, General Hospital of Northern Theater Command, Shenyang 110001, China.
L GuoDepartment of Rheumatology and Immunology, General Hospital of Northern Theater Command, Shenyang 110001, China.
R SunDepartment of Rheumatology and Immunology, General Hospital of Northern Theater Command, Shenyang 110001, China.
Y LiDepartment of Rheumatology and Immunology, General Hospital of Northern Theater Command, Shenyang 110001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo detect the expression levels of absence in melanoma 2 (AIM2), cysteine aspartate-specific protease-1 (caspase-1), and gasdermin D (GSDMD) in peripheral blood mononuclear cell (PBMC) of patients with idiopathic inflammatory myopathy (IIM) and to explore their role in the pathogenesis of IIM.

methodsA total of 30 IIM patients (IIM group) who visited the Department of Rheumatology and Immunology, General Hospital of Northern Theater Command from May 2020 to June 2022 were recruited. Concurrently, 30 healthy volunteers matched by gender and age were recruited from the hospital's Health Examination Center. Clinical information, biochemical and immunological mar-kers, and venous blood samples were collected from the study subjects. Serum double-stranded DNA (dsDNA) levels were detected by fluorescence quantitative method, and the mRNA expression levels of

resultsThe IIM group included 10 cases of dermatomyositis (DM), 5 cases of polymyositis (PM), 11 cases of overlap syndrome (OM), and 4 cases of immune-mediated necrotizing myopathy (IMNM). Compared with the healthy control group, the serum levels of dsDNA, IL-1β, and IL-18 were significantly increased in the IIM group and its subgroups (

conclusionThe AIM2 inflammasome-mediated pyroptosis pathway may be involved in the pathogenesis of IIM, providing a theoretical basis for further research on the etiology of IIM and the development of new therapies.

Indexed as

DNA-Binding ProteinsLeukocytes, MononuclearMyositisNeoplasm ProteinsPyroptosisAdultAgedCase-Control StudiesCaspase 1FemaleGasderminsHumansInterleukin-18Interleukin-1betaIntracellular Signaling Peptides and ProteinsMaleAIM2 protein, humanCaspase 1DNA-Binding ProteinsGasderminsGSDMD protein, humanInterleukin-18Interleukin-1betaIntracellular Signaling Peptides and ProteinsNeoplasm ProteinsPhosphate-Binding ProteinsRNA, MessengerAbsent in melanoma 2Caspase-1Gasdermin DIdiopathic inflammatory myopathyPyroptosis

Identifiers

PMID41633601
PMCPMC12872306

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