Evidence map›Paper›PMID 41633532›Full record

ArticleJornal de pediatria

PIM2, lactate, and trauma score to predict mortality in critically ill pediatric trauma patients.

Luciana G Barcellos, Fernanda M Rubin, Ana Paula P da Silva, Júlia L Vieira, Luciane G da Cunha, Lucinara V Enéas Machado, Geniara da S Conrado, Cristian T Tonial

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Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Luciana G BarcellosHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Fernanda M RubinHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Ana Paula P da SilvaHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Júlia L VieiraHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Luciane G da CunhaHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Lucinara V Enéas MachadoHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Geniara da S ConradoHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil.
Cristian T TonialHospital de Pronto Socorro de Porto Alegre, Pediatric Trauma Intensive Care Unit, Porto Alegre, RS, Brazil; Hospital de Clínicas de Porto Alegre (HCPA), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: cristiantonial@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the prognostic performance of the Pediatric Index of Mortality 2 (PIM2), serum lactate, and Pediatric Trauma Score (PTS) for mortality in a large case series of critically ill pediatric trauma patients admitted to a specialized PICU in Brazil.

methodsRetrospective case series conducted in the Pediatric Intensive Care Unit of a tertiary trauma hospital in Brazil. All trauma patients aged 1 month to 18 years admitted between March 2018 and March 2025 and hospitalized for >24 h were eligible (n = 1495). Demographic, clinical, and laboratory data were collected, including PIM2, initial lactate, and PTS. The primary outcome was all-cause PICU mortality.

resultsDeath occurred in 1.5% of patients. ROC curve analysis was performed in 620 patients with complete data for the three markers. Areas under the curve (AUCs) were: PIM2, 0.93 (95% CI, 0.91-0.95); lactate, 0.86 (95% CI, 0.83-0.88); and PTS, 0.82 (95% CI, 0.79-0.85). In univariable logistic regression, all markers were independently associated with mortality. A 10-fold increase in PIM2 and lactate raised death odds by 36-fold and 226-fold, respectively, while each point increase in PTS reduced odds by 34.6%. In the multivariable model, PIM2 and lactate remained significant predictors.

conclusionsPIM2 and lactate remained independently associated with mortality after mutual adjustment in pediatric trauma patients admitted to a specialized PICU. PTS, while valuable for prehospital triage, added little once intensive care was initiated.

Indexed as

Critical IllnessLactic AcidTrauma Severity IndicesWounds and InjuriesAdolescentBiomarkersBrazilChildChild, PreschoolFemaleHospital MortalityHumansInfantInjury Severity ScoreIntensive Care Units, PediatricMaleBiomarkersLactic AcidIntensive Care UnitsLactic acidPediatricPediatricsPrognosisTrauma CentersWounds and injuries

Identifiers

PMID41633532
PMCPMC12926633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.