Evidence map›Paper›PMID 41632929›Full record

ArticleJournal of proteome research2026

Metabolic Adaptation during Cardiac Exercise Rehabilitation in Patients after a First Myocardial Infarction.

Eleonora Bossi, Marta Nobile, Federico Paoletti, Lorenzo Ticini, Simone Serrao, Alessia Giglio, Gianfranco Parati, Antonio Zaza, Lia Crotti, Gabriella Malfatto and 1 more

Abstract read
In one paragraph

Article in Journal of proteome research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eleonora BossiDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.ORCID 0009-0006-4070-4119
Marta NobileDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.
Federico PaolettiDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.
Lorenzo TiciniDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.
Simone SerraoDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.ORCID 0000-0002-1881-856X
Alessia GiglioIRCCS, Istituto Auxologico Italiano, Department of Cardiology, Cardiac Rehabilitation Unit, S. Luca Hospital, Piazzale Brescia 20, Milan 20149, Italy.
Gianfranco ParatiIRCCS, Istituto Auxologico Italiano, Department of Cardiology, Cardiac Rehabilitation Unit, S. Luca Hospital, Piazzale Brescia 20, Milan 20149, Italy.
Antonio ZazaDepartment of Biotechnology & Bioscience, University of Milano-Bicocca, Milano 20126, Italy.
Lia CrottiDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.
Gabriella MalfattoIRCCS, Istituto Auxologico Italiano, Department of Cardiology, Cardiac Rehabilitation Unit, S. Luca Hospital, Piazzale Brescia 20, Milan 20149, Italy.
Giuseppe PagliaDepartment of Medicine and Surgery, University of Milano-Bicocca, Monza 20900, Italy.ORCID 0000-0003-4724-6801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac rehabilitation (CR) is highly beneficial in postmyocardial infarction (MI) patients; however, its metabolic impact remains underexplored. This study investigated metabolic and lipidomic adaptations to an intensive CR program in 25 nondiabetic male patients (<75 years) following a first uncomplicated ST-elevation MI (STEMI). CR involved 24 ± 3 sessions, with baseline and final clinical assessments, and, in a subgroup of 17 patients, longitudinal dried blood spots (DBS) were collected, and metabolomics/lipidomics analysis was also performed. CR significantly improved clinical outcomes, including the 6 min walk test, B-type natriuretic peptide (BNP), left ventricular ejection fraction (LVEF%), C-reactive protein (CRP), and homocysteine levels. Metabolomic analysis showed sustained metabolic adaptations, notably increased

Indexed as

Adaptation, PhysiologicalExercise TherapyMyocardial InfarctionST Elevation Myocardial InfarctionAgedC-Reactive ProteinEnergy MetabolismHomocysteineHumansLipidomicsMaleMetabolomicsMiddle AgedNatriuretic Peptide, BrainPhosphatidylserinesC-Reactive ProteinHomocysteineNatriuretic Peptide, BrainPhosphatidylserinesacute myocardial infarctioncardiac rehabilitationdried blood spotslipidomicsmetabolomicsphysical training

Identifiers

PMID41632929
PMCPMC12973364

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.