Evidence map›Paper›PMID 41632848›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Molecular tuning of DNA framework-programmed silicification by cationic silica cluster attachment.

Xinxin Jing, Haozhi Wang, Jianxiang Huang, Yingying Liu, Zimu Li, Jielin Chen, Yiqun Xu, Lingyun Li, Yunxiao Lin, Damiano Buratto and 8 more

Abstract read
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In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Xinxin Jing *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Haozhi Wang *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0006-7777-2668
Jianxiang Huang *Institute of Quantitative Biology, College of Life Sciences, and Department of Physics, Zhejiang University, Hangzhou 310058, China.
Yingying Liu *State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Zimu LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Jielin ChenState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-4930-2870
Yiqun XuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Lingyun LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Yunxiao LinState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Damiano BurattoInstitute of Quantitative Biology, College of Life Sciences, and Department of Physics, Zhejiang University, Hangzhou 310058, China.
Qinglin XiaDivision of Physical Biology, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Muchen PanDivision of Physical Biology, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.ORCID 0000-0002-7703-8061
Yue WangDivision of Physical Biology, Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Mingqiang LiState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Ruhong ZhouInstitute of Quantitative Biology, College of Life Sciences, and Department of Physics, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-8624-5591
Stephen MannSchool of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Chunhai FanState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-7171-7338
Xiaoguo LiuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-7834-399X

Funding

MOST | National Key Research and Development Program of China (NKPs) 2023YFA0915200MOST | National Natural Science Foundation of China (NSFC) 22322205MOST | National Natural Science Foundation of China (NSFC) 92056117MOST | National Natural Science Foundation of China (NSFC) U1967217National Center of Technology Innovation for Biopharmaceuticals NCTIB2022HS02010National Independent Innovation Demonstration Zone Shanghai Zhangjiang Major Projects ZJZX2020014Shanghai AI Lab P22KN00272Shanghai Municipal Science and Technology Major ProjectStarry Night Science Fund of Zhejiang University Shanghai Institute for Advanced Study SN-ZJU-SIAS-003
6 · The paper itself

Abstract

The organizational complexity of biominerals has long fascinated scientists seeking to understand biological programming and implement new developments in biomimetic materials chemistry. Nonclassical crystallization pathways have been observed and analyzed in typical crystalline biominerals, such as calcium phosphate, calcium carbonate, and ferric oxide, involving the controlled attachment and reconfiguration of nanoparticles and clusters on organic templates. However, the understanding of templated amorphous silica mineralization remains limited, hindering the rational design of complex silica-based materials. Here, we report the finding of ultrastable and monodispersed cationic silica cluster (CSC) and their assembly using DNA nanostructures as programmable attachment templates. Cryo-EM imaging reveal that a typical CSC with a diameter of gyration of ~3.9 nm and an average molecular weight of ~8, 262 Da is characteristic of a branched hierarchical structure. We demonstrate high-fidelity silicification by tuning the composition and structure of CSC, providing a unified model of silicification by cluster attachment. Our findings pave the way toward the molecular tuning of pre- and postnucleation stages of sol-gel reactions and provide insights for the design of silica-based materials with controlled organization and functionality.

Indexed as

DNASilicon DioxideCationsCryoelectron MicroscopyCrystallizationDNA NanostructuresCationsDNASilicon Dioxideamorphous silicabiomineralsDNA nanotechnology

Identifiers

PMID41632848
PMCPMC12890976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.