SynthesisDigestive diseases (Basel, Switzerland)2026
Nasopharyngeal Methicillin-Resistant <italic>Staphylococcus aureus</italic> Carriage and Risk of Percutaneous Endoscopic Gastrostomy-Related Infection: A Systematic Review and Meta-Analysis.
Synthesis in Digestive diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
<p>Introduction: Enteral feeding via percutaneous endoscopic gastrostomy (PEG) is commonly used for patients requiring long-term nutritional support. However, PEG insertion carries a risk of infection, including methicillin-resistant Staphylococcus aureus (MRSA) peristomal infections. This systematic review and meta-analysis aimed to evaluate the association between MRSA colonization and the risk of PEG-related infections.
methodsA systematic search was conducted in four major databases - Embase, MEDLINE, Cochrane, and Scopus - focusing on studies reporting MRSA colonization and PEG-related infections. Data were analyzed using RevMan v5.3. Odds ratios (OR) were calculated for dichotomous outcomes using a random-effects model. Statistical significance was defined as p < 0.05. Heterogeneity was assessed using the I2 statistic.
resultsFive studies encompassing 286 patients were included in the meta-analysis. Among them, 77 patients were nasopharyngeal MRSA-positive, and 209 were MRSA-negative. MRSA colonization was significantly associated with an increased risk of PEG-related peristomal infection (OR: 24.31; 95% CI: 5.20-113.65; p < 0.0001). Moderate heterogeneity was observed among studies (I2 = 69%, p = 0.01), likely reflecting differences in study design and infection definition; however, the overall association remained statistically significant.
conclusionNasopharyngeal MRSA colonization is strongly associated with a higher risk of PEG-site infection. These findings highlight the importance of MRSA screening and consideration of colonization status prior to PEG tube insertion. Enhanced infection control strategies should be implemented in MRSA-positive patients to reduce the risk of complications. However, given the limited number of included studies (n = 5; 286 patients), these conclusions should be interpreted with caution. Larger, well-designed studies are needed to validate these associations and identify the most effective preventive measures for MRSA-colonized individuals undergoing PEG placement. </p>.
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