Trial reportThe Journal of frailty & aging2026
A multicomponent intervention consisting of exercise, proteins and omega-3 supplementation to improve sarcopenia in community-dwelling older adults: Lessons learned from a 5-armed randomized controlled feasibility trial.
Trial report in The Journal of frailty & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03649698 (Exercise and Nutrition for Healthy AgeiNg), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise and Nutrition for Healthy AgeiNg: Anabolic Interventions for Older People With (Pre)Sarcopenia to Improve Physical Functioning, Muscle Mass and Muscle Strength and to Understand the Underlying Mechanisms of Action.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnabolic interventions, including physical exercise, proteins and omega-3 polyunsaturated fatty acids (PUFAs) supplementation, have shown effectiveness in improving sarcopenia outcomes. However, data on their combined effects in older adults with sarcopenia remain limited.
objectivesTo assess feasibility, acceptability, and preliminary effects of a multicomponent intervention combining individualized home-based exercise, proteins, and/or omega-3 supplementation.
designParallel five-armed randomized assessor-blinded controlled feasibility trial with triple-blinded supplementation. PARTICIPANTS AND
settingCommunity-dwelling older adults (≥65 years) diagnosed with sarcopenia (EWGSOP2-criteria) from the Exercise and Nutrition for Healthy Ageing (ENHANce) study. The ENHANce study was registered on ClinicalTrials.gov (NCT03649698).
interventionParticipants were randomized into 5 groups: 1) Exercise, 2) Proteins, 3) Exercise+Protein, 4) Exercise+Protein+Omega-3, and 5) Control group. MEASUREMENTS: Feasibility was assessed via eligibility, recruitment, retention, and data completion rates. Acceptability was evaluated through participants' feedback, adherence, and safety. Effects were measured by changes in sarcopenia outcomes after 12 weeks.
resultsFifty-eight participants (76.2±6.6years,♀:65.5%) were included (Exercise,n=9;Protein,n=12; Exercise+Protein,n=13;Exercise+Protein+Omega-3;n=12;Control,n=12). Feasibility was low, with a recruitment rate of 2%. Acceptability was moderate, with most participants completing the planned assessments and reporting positive experiences such as feeling stronger and more aware of the importance of physical activity and nutrition. However, many found the study procedures demanding, and many experienced difficulties with the protein supplements. Adherence varied widely across interventions. Safety was high, with no significant adverse effects reported. The interventions showed potential to improve chair stand test (CST), Short Physical Performance Battery (SPPB), muscle mass and quadriceps strength.
conclusionA multicomponent intervention to treat sarcopenia showed low feasibility, moderate acceptability, and high safety. Preliminary efficacy results showed that exercise with protein supplementation may improve physical function. Adding omega-3 PUFA might offer further benefits for muscle strength and mass, but should be confirmed in larger studies. The insights and the practical challenges in the ENHANce study inform future sarcopenia intervention designs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.