Evidence map›Paper›PMID 41632503›Full record

ArticleACS applied materials & interfaces2026

Iron-Responsive Deferasirox Release from Covalently Grafted Hydrogels on Microwires Extends Iron Chelation Time Scales.

Jarek A Maleszka, Elvis Attah, Ifigeneia Tsironi, Melissa Franklin, Brianna Bernard, Jordan L Grant, Grant M Lee, Margaret Lewis, Sariah Byrd, Abhishek Prasad and 1 more

Abstract read
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In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jarek A MaleszkaDepartment of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States.
Elvis AttahDepartment of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States.
Ifigeneia TsironiDepartment of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID 0000-0002-6107-4383
Melissa FranklinDepartment of Biomedical Engineering, University of Miami, Coral Gables, Florida 33146, United States.
Brianna BernardDepartment of Chemistry, University of Miami, Coral Gables, Florida 33146, United States.
Jordan L GrantDepartment of Biomedical Engineering, University of Miami, Coral Gables, Florida 33146, United States.ORCID 0009-0004-8189-2158
Grant M LeeDepartment of Biomedical Engineering, University of Miami, Coral Gables, Florida 33146, United States.
Margaret LewisDepartment of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States.
Sariah ByrdDepartment of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States.
Abhishek PrasadDepartment of Biomedical Engineering, University of Miami, Coral Gables, Florida 33146, United States.
Jean-Hubert OlivierDepartment of Chemistry and Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID 0000-0003-0978-4107

Funding

Effects of Iron Accumulation in Intracortical Implants and Protection by Iron ChelationR01NS126269 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Abhishek Prasad · 2023 to 2026
$2.2M
NINDS NIH HHS R01 NS126269
6 · The paper itself

Abstract

Implantation of intracortical microelectrodes generates free iron species that exacerbate pro-inflammatory responses by producing reactive oxygen species through the Fenton reaction. This work reports a covalently grafted, two-layer poly(ethylene glycol)dimethacrylate (PEGDMA) hydrogel on polyimide-insulated Pt/Ir microwires for local delivery of the iron chelator deferasirox (DFO). The polyimide insulating layer was methacrylated to enable covalent anchoring of a PEGDMA550 interlayer, followed by a DFO-loaded PEGDMA3400 outer layer. Scanning electron microscopy and optical microscopy of the hydrogel-coated microwires revealed a uniform coating morphology with dispersed DFO aggregates embedded within the matrix. In buffer at 37 °C, DFO release followed diffusion-controlled kinetics and fell below the limit of detection by ultraperformance liquid chromatography by day 9. The iron-chelation properties of the DFO-loaded microwires were investigated using Fe(EDTA) as a free-iron mimic. When a high concentration of Fe(EDTA) was used (10 mM), the Fe(DFO)

Indexed as

DeferasiroxHydrogelsIronIron Chelating AgentsMethacrylatesMicroelectrodesPolyethylene GlycolsDeferasiroxHydrogelsIronIron Chelating AgentsMethacrylatespoly(ethylene glycol)-dimethacrylatePolyethylene Glycolsdrug deliveryhydrogelsiron chelatormicrowiresnanoarchitectonics

Identifiers

PMID41632503
PMCPMC13097048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.