ArticleClinical cancer research : an official journal of the American Association for Cancer Research2026
Longitudinal ctDNA Monitoring for Postsurgical Disease Surveillance in Patients with Stage I to IIIB Melanoma.
Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Circulating Tumor DNA as a Biomarker for Melanoma Prognosis and Therapy.American journal of clinical dermatology · 2026Review
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- Review
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- Sensitivity and prognostic significance of circulating tumor DNA (ctDNA) in stage I to III malignant melanoma.Journal of cancer research and clinical oncology · 2026Article
- Circulating Tumor DNA in Melanoma: Advances in Detection, Clinical Applications, and Integration with Emerging Technologies.International journal of molecular sciences · 2026Review
- Peripheral blood biomarkers in PD-1/PD-L1 immunotherapy: distinguishing predictive from prognostic biomarkers.Frontiers in immunology · 2026Review
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Authors and funding
23 authors.
Funding
Abstract
purposeCirculating tumor DNA (ctDNA) has emerged as an important biomarker for early recurrence detection and disease status monitoring during treatment in patients with cancer, including melanoma. We evaluate the prognostic value and impact of postoperative ctDNA detection in patients with stage I to IIIB melanoma using a clinically validated ctDNA assay. EXPERIMENTAL
designWe conducted a retrospective analysis of real-world data of patients with stage I to IIIB melanoma, including ctDNA results using a personalized, tumor-informed, 16-plex multiplex PCR-next-generation sequencing assay. Adjuvant treatment decisions and postsurgical plasma sample collection timepoints were at the physician's discretion. ctDNA results were correlated with clinical outcomes.
resultsAcross 190 patients and a total of 1,578 samples, a median of 7 ctDNA tests (range: 1-33) per patient were performed over a median period of 24.6 months (range: 3.7-74.7). ctDNA positivity at any postoperative timepoint was significantly associated with shorter recurrence-free survival [RFS; hazard ratio (HR): 40.63; 95% confidence interval (CI), 19.9-82.96; P < 0.0001). This finding was also observed in patients specifically with regional or distant recurrence (HR: 39.55; 95% CI, 18.08-86.51; P < 0.0001). In multivariate analysis, ctDNA positivity was the most significant prognostic factor associated with RFS when compared with other clinicopathologic factors, including stage, sex, and mitotic rate (HR: 25.36; 95% CI, 9.16-70.3; P < 0.001).
conclusionsOur findings highlight the prognostic value of postsurgical, personalized ctDNA detection of recurrence and longitudinal disease surveillance in stage I to IIIB melanoma. The impact of ctDNA on real-world clinical decision-making highlights the need to assess outcomes when cancer management is influenced by ctDNA dynamics.
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