Evidence map›Paper›PMID 41632429›Full record

ArticleProbiotics and antimicrobial proteins2026

Probiotic Lactobacillus johnsonii RS-7 Alleviates Intestinal Inflammation Via the TLR4/MyD88/NF-κB Signaling Pathway.

Heng Yin, Chengbi Wang, Kai Zhao, Jianfei Zhao, Liang Chen, Hongfu Zhang, Shanchuan Cao, Jingbo Liu

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Strain-resolved biology ofFrontiers in veterinary science · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Heng Yin *College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China.
Chengbi Wang *College of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China.
Kai ZhaoCollege of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China.
Jianfei ZhaoCollege of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China.
Liang ChenState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China.
Hongfu ZhangState Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China.
Shanchuan CaoCollege of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China.
Jingbo LiuCollege of Life Sciences and Agri-forestry, Southwest University of Science and Technology, Mianyang, 621010, China. jingboliu@swust.edu.cn.

Funding

Southwest University of Science and Technology 25zx7108
6 · The paper itself

Abstract

Developing novel probiotics can help in preventing livestock diarrhea and associated intestinal diseases. Lactic acid bacteria (LAB) are symbiotic intestinal bacteria, which contribute to gastrointestinal tract health. An LAB strain, designated L. johnsonii RS-7, was isolated from the feces of healthy adult pigs and was resistant to acidic conditions and bile salts. In vitro evaluation showed significant antioxidant and anti-inflammatory properties, suggesting its potential application in alleviating intestinal inflammation. An artificially induced colitis model was established in mice to investigate the efficacy of L. johnsonii RS-7. Results indicated that mice administered water containing 3% DSS developed pronounced colitis symptoms, characterized by weight loss, elevated disease activity index, shortened colon length, microvilli shedding, tight junction disruption, reduced goblet cell counts, suppression of anti-inflammatory cytokines, activation of pro-inflammatory cytokines and the TLR4/MyD88/NF-κB signaling pathway, and impaired gut microbiota diversity. These suggest that oral administration of L. johnsonii RS-7 significantly alleviated colitis symptoms. In summary, L. johnsonii RS-7 acted as a probiotic by inhibiting activation of the TLR4/MyD88/NF-κB pathway.

Indexed as

ColitisLactobacillus johnsoniiMyeloid Differentiation Factor 88NF-kappa BProbioticsToll-Like Receptor 4AnimalsGastrointestinal MicrobiomeMaleMiceSignal TransductionSwineMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseToll-Like Receptor 4ColonGut microbiotaInflammationLactobacillus johnsoniiTLR4/MyD88/NF-κB pathway

Identifiers

PMID41632429

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.