Evidence map›Paper›PMID 41632420›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026

NIR enhanced nanozyme and synergy with ineffective antibiotic activities of BSA-Ag

Deyou Zhao, Songtai Gao, Xiaowei Tian, Xiaowen Liu, Zhong Lu, Huaiying Yao

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Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Deyou Zhao *Hubei Key Laboratory of Microbial Transformation and Regulation of Biogenic Elements in the Middle Reaches of the Yangtze River, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Songtai Gao *Hubei Key Laboratory of Microbial Transformation and Regulation of Biogenic Elements in the Middle Reaches of the Yangtze River, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Xiaowei TianHubei Key Laboratory of Microbial Transformation and Regulation of Biogenic Elements in the Middle Reaches of the Yangtze River, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Xiaowen LiuHubei Key Laboratory of Microbial Transformation and Regulation of Biogenic Elements in the Middle Reaches of the Yangtze River, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China.
Zhong LuHubei Key Laboratory of Microbial Transformation and Regulation of Biogenic Elements in the Middle Reaches of the Yangtze River, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China. zhonglu@wit.edu.cn.ORCID http://orcid.org/0000-0002-5918-1489
Huaiying YaoHubei Key Laboratory of Microbial Transformation and Regulation of Biogenic Elements in the Middle Reaches of the Yangtze River, School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan, 430205, China. hyyao@iue.ac.ORCID http://orcid.org/0000-0002-1932-8765

Funding

National Natural Science Foundation of China 42276164
6 · The paper itself

Abstract

With the prevalence of antibiotic-resistant bacteria (ARB), the antibacterial strategy based on combining multiple antibacterial pathways in one agent provides a promising way to combat ARB infections. Here, we reported that bovine serum albumin (BSA)-Ag2Te nanoparticles (NPs) could partially recover the antibacterial activity of ineffective β-lactam antibiotic cefotaxime (CTX) against methicillin-resistant Staphylococcus aureus (MRSA) by inhibiting β-lactamase and increasing membrane permeability of MRSA. The lower fractional inhibitory concentration index (0.187) and the combination index (≤ 0.68 ) provided the higher synergistic bactericidal activity of BSA-Ag2Te and CTX. Furthermore, BSA-Ag2Te NPs exhibited high near-infrared (NIR)-induced photothermal conversion and NIR-enhanced peroxidase-mimicking activities. Both the hyperthermia produced by NIR irradiation and ·OH generated through catalyzing H2O2 significantly enhanced the synergistic antibacterial activity of BSA-Ag2Te with CTX against MRSA. Over a short irradiation time (10 min), BSA-Ag2Te + CTX + H2O2 + NIR decreased 3.8 log10 of MRSA, which is higher than that of BSA-Ag2Te + CTX + NIR (2.8 log10) or BSA-Ag2Te + CTX + H2O2 (1.4 log10). Such a multiple-mode antibacterial platform based on BSA-Ag2Te NPs and ineffective CTX may provide an effective strategy to overcome refractory MRSA infections.

Indexed as

Anti-Bacterial AgentsInfrared RaysMethicillin-Resistant Staphylococcus aureusNanoparticlesSerum Albumin, BovineSilver CompoundsAnimalsCattleCefotaximeMicrobial Sensitivity TestsAnti-Bacterial AgentsCefotaximeSerum Albumin, BovineSilver CompoundsBSA-Ag2Te nanoparticlesIneffective antibioticMethicillin-resistant Staphylococcus aureusPeroxidase-like activityPhotothermal conversionSynergy

Identifiers

PMID41632420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.