ArticleJournal of neuro-oncology2026
Socioeconomic disparities in glioma outcomes: a grade-specific analysis.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Integrated clinico-radio-molecular profiling of diffuse gliomas across age groups: a Romanian single-center cohort study.Journal of medicine and life · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSocioeconomic deprivation influences outcomes across numerous neurosurgical conditions, yet its impact on glioma remains poorly characterised. This study examined whether area-level deprivation, measured by the Index of Multiple Deprivation (IMD), was associated with survival and perioperative outcomes following glioma resection.
methodsThis retrospective cohort study analysed 199 adults undergoing surgical resection for WHO Grade 2–4 gliomas at a UK tertiary neurosurgical centre between 2010 and 2024. Patients were stratified by IMD quintile. Primary outcomes were overall survival (OS) and progression-free survival (PFS). Multivariable Cox regression models adjusted for age, molecular markers (IDH mutation, MGMT methylation), and preoperative functional status, with separate analyses by tumour grade.
resultsExtent of resection and receipt of adjuvant therapy did not differ significantly across IMD quintiles (extent of resection p = 0.123). IMD quintile was not associated with OS in any grade. However, in Grade 4 gliomas (n = 122; n = 88 for complete case analysis), higher socioeconomic status was associated with longer PFS (HR 0.72 per quintile increase, 95% CI 0.55–0.94, p = 0.017), representing a 28% reduction in progression risk per quintile. No associations were observed for Grade 2 or 3 tumours, nor for perioperative complications, reoperation rates, or functional decline.
conclusionsSocioeconomic deprivation was associated with earlier disease progression in glioblastoma following adjustment for established prognostic factors and extent of resection. The absence of perioperative disparities and equitable treatment initiation suggests inequalities emerge during longitudinal oncological care rather than surgical treatment. These findings highlight the need for healthcare systems to address socioeconomic barriers in neuro-oncology pathways.
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Registered trials
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