ArticleJournal of neuro-oncology2026
FOXC1 expression and radiological predictors of peritumoral brain edema in meningiomas.
Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- FOXC1 as a molecular predictor of postoperative peritumoral edema resolution in meningiomas.Journal of neuro-oncology · 2026Article
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7 authors.
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Abstract
backgroundPeritumoral brain edema (PTBE) is a frequent finding in meningiomas and can significantly affect perioperative outcomes. In addition to well-established clinical, radiological, and histopathological risk factors, molecular markers such as Forkhead Box C1 (FOXC1) may also play a crucial role in the development of PTBE.
methodsWe conducted a retrospective, single-center study including 86 patients with histopathologically confirmed meningiomas. Preoperative MRI datasets were analyzed for tumor characteristics using 3D Slicer and ImageJ. FOXC1 expression was assessed immunohistochemically and dichotomized based on receiver operating characteristic (ROC) curve analysis. Univariate analyses were performed to evaluate associations between clinical, radiological, and histopathological variables and the presence of PTBE.
resultsPTBE was significantly associated with low FOXC1 expression (p = 0.015). Furthermore, WHO grade 2/3 meningiomas (p = 0.012), perioperative seizures (p = 0.024), subtype (p = 0.016), tumor laterality (p = 0.04), higher MIB-1 index (p < 0.001) and tumor volume (p = 0.01) were also significantly associated with PTBE. Tumor localization (skull base vs. non-skull-base) and sex showed no significant correlation.
conclusionCombining molecular and radiological parameters could improve neurosurgical planning and perioperative management. Further studies are needed regarding the assessment of the response to anti-edematous therapies in low and high FOXC1 expressing meningiomas.
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