Evidence map›Paper›PMID 41632300›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2026

m5c-modified LINC01094 participates in epithelial-mesenchymal transition and metastasis of cervical cancer cells via the ZNF582-SIRT1/p53 axis.

Xia Lu, Lili Yao, Xu Xu, Mayinuer Guli Rexiti, Xiaoli He, Yanyan Yang

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Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xia Lu *Institute of Medical Sciences of Xinjiang Medical University, Urumqi, 830054, China.
Lili Yao *Third Department of Gynecological Surgery, Xinjiang Medical University Affiliated Cancer Hospital, Urumqi, 830011, China.
Xu XuDepartment of Obstetrics and Gynecology, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, China.
Mayinuer Guli RexitiDepartment of Obstetrics and Gynecology, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, China.
Xiaoli HeDepartment of Obstetrics and Gynecology, the Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, China.
Yanyan YangPathology Department, The Sixth Affiliated Hospital of Xinjiang Medical University, No. 39 Wuxing South Road, Tianshan District, Urumqi, 830000, Xinjiang, China. LJM110122@163.com.

Funding

Open Project Program of Institute of Medical Sciences of Xinjiang Medical University YXYJ20240205
6 · The paper itself

Abstract

Cervical cancer (CC) remains a significant global health burden despite advances in prevention and screening. Emerging evidence highlights the critical role of long non-coding RNAs (lncRNAs) and RNA modifications in tumorigenesis. Here, we identified LINC01094 as a highly expressed lncRNA in CC through TCGA analysis and clinical specimens. Functional studies, including CCK-8 method, flow cytometry, Transwell and Western blot assays, demonstrated that LINC01094 knockdown suppressed cell proliferation, migration, and epithelial-mesenchymal transition while promoting apoptosis in CC cells (Caski and SiHa). Mechanistically, NSUN2-mediated 5-methylcytosine methylation stabilized LINC01094, enhancing its expression in CC. Furthermore, LINC01094 facilitated ZNF582-dependent transcriptional activation of SIRT1, promoted the deacetylation and degradation of p53. Rescue experiments confirmed that ectopic expression of either LINC01094 or SIRT1 reversed the tumor-suppressive effects of NSUN2 or LINC01094 knockdown, respectively. Collectively, NSUN2-mediated stabilization of LINC01094 upregulated SIRT1 expression, thereby suppressing the p53 pathway and accelerating CC progression. These findings uncover a novel NSUN2/LINC01094/SIRT1 axis as an epigenetic-transcriptional driver of CC, offering potential therapeutic targets.

Indexed as

Epithelial-Mesenchymal TransitionRNA, Long NoncodingSirtuin 1Tumor Suppressor Protein p53Uterine Cervical Neoplasms5-MethylcytosineApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMethyltransferasesNeoplasm MetastasisRNA Methylation5-MethylcytosineMethyltransferasesNSUN2 protein, humanRNA, Long NoncodingSIRT1 protein, humanSirtuin 1TP53 protein, humanTumor Suppressor Protein p535-methylcytosineCervical cancerEpithelial-mesenchymal transitionLINC01094Metastasis

Identifiers

PMID41632300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.