ReviewClinical reviews in allergy & immunology2026
Neuro-immune Crosstalk in Atopic Dermatitis: A Multiaxial Regulatory Network and Novel Therapeutic Perspectives.
Review in Clinical reviews in allergy & immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Atopic dermatitis (AD) is a chronic inflammatory disorder driven by complex neuro‑immune interactions beyond classical immune dysregulation. Previous reviews have largely focused on local peripheral neuro‑immune circuits mediating itch and inflammation, but they have not provided an integrative framework connecting peripheral, systemic, and psychological axes. Here, we propose a “multi‑axial neuro‑immune regulatory network” unifying cutaneous, central, and gut–brain–skin pathways to explain the systemic and psychosomatic nature of AD. We highlight neuroplastic remodeling, psycho-neuro-immunologic mechanisms, and therapeutic innovations that target these intertwined axes. This conceptual framework extends beyond prior literature by positioning AD as a dynamic neuro‑immune disorder rather than a purely epithelial or allergic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.