ArticleArchives of microbiology2026
Impact of extracellular vesicles from various species of Candida fungi on the cross-species interactions with human epithelial cells.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Machine-Learning Prediction of Extracellular Vesicle Protein Sorting Expands the Characterization of Secretory Functions inJournal of fungi (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Candida species are members of the human microbiota but can become pathogenic when host homeostasis is disrupted. Among the species responsible for human fungal infections are C. albicans, C. tropicalis, and Nakaseomyces glabratus (formerly classified as C. glabrata). These fungi employ multiple strategies to colonize host niches, including phenotypic and morphological plasticity, biofilm formation in mono- or multispecies communities, secretion of virulence factors, and release of extracellular vesicles (EVs). Adhesion of fungal cells to host tissues is a critical step in the establishment and progression of infection, particularly in systemic candidiasis, and may be influenced by EV-mediated interactions. In this study, we investigated the adhesion of selected Candida species to human epithelial cells, focusing on the role of fungal EVs in cross-species interactions. Our results reveal species-specific outcomes in these interactions. We further identified the fungal adhesin Als3 and the host protein E-cadherin as key cell-surface molecules mediating interactions between cells and EVs. Overall, our findings demonstrate that fungal EVs contribute to adhesion across different Candida species and implicate specific surface proteins in this process, highlighting a conserved yet species-specific role for EVs in host-pathogen interactions.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.