Evidence map›Paper›PMID 41632085›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Single-Cell Transcriptomic Atlases of Camels and Cattle Unravel Molecular Evolution of Digestive and Metabolic Systems.

Tao Shi, Huiquan Shan, Haoping Wang, Xi Guo, Houcheng Li, Bo Han, Senlin Zhu, Fei Wang, Guanghui Tan, Zhannur Niyazbekova and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Tao ShiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Huiquan ShanKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Haoping WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xi GuoKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Houcheng LiCenter for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark.
Bo HanKey Laboratory of Animal Genetics, National Engineering Laboratory For Animal Breeding, Department of Animal Genetics, College of Animal Science and Technology, Breeding and Reproduction, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing, China.
Senlin ZhuInstitute of Dairy Science, College of Animal Sciences, Ministry of Education Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, China.
Fei WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Guanghui TanKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Zhannur NiyazbekovaReference center For Safety and Quality of Agricultural Products, Kazakh National Agrarian Research University, Almaty, Kazakhstan.
Jilong RenKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Yaqi ZhouKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Qi ZhangKey Laboratory of Animal Genetics, National Engineering Laboratory For Animal Breeding, Department of Animal Genetics, College of Animal Science and Technology, Breeding and Reproduction, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing, China.
Weijie ZhengKey Laboratory of Animal Genetics, National Engineering Laboratory For Animal Breeding, Department of Animal Genetics, College of Animal Science and Technology, Breeding and Reproduction, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing, China.
Minghui JiaInstitute of Dairy Science, College of Animal Sciences, Ministry of Education Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, China.
Ao ZhangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xuesha CaoKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Huizeng SunInstitute of Dairy Science, College of Animal Sciences, Ministry of Education Key Laboratory of Molecular Animal Nutrition, Zhejiang University, Hangzhou, China.
Dongxiao SunKey Laboratory of Animal Genetics, National Engineering Laboratory For Animal Breeding, Department of Animal Genetics, College of Animal Science and Technology, Breeding and Reproduction, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, China Agricultural University, Beijing, China.
Lingzhao FangCenter for Quantitative Genetics and Genomics, Aarhus University, Aarhus, Denmark.
Yi ZhengKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Xihong WangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Yu JiangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China.ORCID https://orcid.org/0000-0003-4821-3585

Funding

Key Science and Technology Special Project of Xinjiang Uygur Autonomous Region 2024A02004National Key R&D Program of China 2022YFF1000100Shaanxi Laboratory Project for Arid Region Agriculture 2024ZY-JCYJ-02-15Shaanxi Livestock and Poultry Breeding Generic Technology Research and Development Platform 2023GXJS-02
6 · The paper itself

Abstract

Cellular and molecular characterization of mammals with multi-chambered stomachs is crucial to our understanding of evolution in digestive and metabolic systems. Here, we generate single-cell transcriptomic atlases of 253,448 and 279,057 cells from 54 tissues in camels and cattle, discovering 124 cell types. Cross-species comparisons at four developmental stages reveal a common evolutionary origin among camel glandular sac, third-chambered stomach, and bovine abomasum, with the camel lineages uniquely harboring a cell population characterized by heightened expression of genes involved in cell proliferation. Also, the advantages of camel hepatocytes in prevention of excessive fat deposition are uncovered. Interestingly, the spatial transcriptomic analysis further reveals a unique population of S100A4

Indexed as

CamelusEvolution, MolecularTranscriptomeAnimalsBiological EvolutionCattleSingle-Cell AnalysisSingle-Cell Gene Expression Analysiscamelcattlekidneymulti‐chambered stomach evolutionsingle‐cell transcriptomic atlas

Identifiers

PMID41632085
PMCPMC13067795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.