Evidence map›Paper›PMID 41632078›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A "Hot Spring" Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming.

Bo Li, Dandan Jin, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang, Shixuan Chen, Yi Zhang

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bo LiDepartment of Burn and Plastic Surgery Department of Wound Repair Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Dandan JinDepartment of Gastroenterology, Affiliated Hospital and Medical School of Nantong University, Nantong, Jiangsu, China.
Fei LiDepartment of Burn and Plastic Surgery Department of Wound Repair Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Jianliang ShenNational Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jiang ChangZhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Chen YangZhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute, University of the Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Shixuan ChenDepartment of Burn and Plastic Surgery Department of Wound Repair Surgery, Affiliated Hospital of Nantong University, Nantong, China.ORCID https://orcid.org/0000-0001-7905-3268
Yi ZhangDepartment of Burn and Plastic Surgery Department of Wound Repair Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Funding

Jiangsu Provincial Research Hospital YJXYY202204National Natural Science Foundation of China 82472550National Natural Science Foundation of China 82472551
6 · The paper itself

Abstract

Chronic wounds, such as diabetic foot ulcers, often exhibit lower temperatures due to impaired local circulation, leading to reduced cellular metabolism and delayed healing. This study explores a new strategy to accelerate wound healing by enhancing the cell metabolism of essential amino acids through a "hot spring" mimetic photothermal effect. We engineered an extracellular matrix mimetic nanofiber aerogel co-delivering an eight essential-amino-acid cocktail and photothermally active SrCuSi4O

Indexed as

AerogelsAmino AcidsInflammationPhotothermal TherapyWound HealingAnimalsHumansAerogelsAmino Acidsamino acidbioceramiccell metabolismchronic woundphotothermal therapy

Identifiers

PMID41632078
PMCPMC13067848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.