Trial reportJournal of the American Heart Association2026
Effects of Acute Exercise and 12-Week High-Intensity Interval Training on Inflammatory Biomarkers in Stable Coronary Artery Disease: A Randomized Controlled Trial.
Trial report in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04268992 (Effect of Long-term Exercise on Haemostasis and Inflammation Compared With Standard Care in Patients With Stable Coronary Artery Disease), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Long-term Exercise on Haemostasis and Inflammation Compared With Standard Care in Patients With Stable Coronary Artery Disease: a Randomised Clinical Trial
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPersistent low-grade inflammation contributes to coronary artery disease (CAD), but how acute vigorous exercise and structured training affect systemic inflammatory biomarkers in stable CAD remains unclear. We evaluated the acute response to a single vigorous bout and the effects of a 12-week high-intensity interval training program on systemic inflammation in patients with stable CAD.
methodsIn 168 patients with stable CAD, blood samples were collected before, immediately after, and 2 hours after a maximal incremental cycling test. Participants were then randomized to 12 weeks of high-intensity interval training or standard care; 142 completed follow-ups. High-sensitivity CRP (C-reactive protein), leukocytes, interleukin-2, interleukin-6, interleukin-10, interferon-γ, and tumor necrosis factor-α were measured at baseline, week 6, and week 12.
resultsAcute exercise elevated CRP by 7.7% [95% CI, 5.5-10.0] and leukocytes by 50.5% [95% CI, 48.2-52.8]; CRP returned to baseline by 2 hours, whereas leukocytes remained elevated. Interferon-γ increased by 13.1% [95% CI, 9.2-17.3] following exercise but fell below baseline after 2 hours. Tumor necrosis factor-α (12.9% [95% CI, 8.4-17.4]), interleukin-2 (22.8% [95% CI, 17.5-28.5]), and interleukin-6 (42.4% [95% CI, 36.5-48.5]) also increased following acute exercise and stayed elevated after 2 hours, while interleukin-10 decreased by 9.2% [95% CI, -14.1 to -4.0] and returned to baseline after 2 hours. Over 12 weeks, high-intensity interval training did not significantly alter these inflammatory markers compared with standard care.
conclusionsAcute strenuous exercise induces transient increases in inflammatory markers in stable CAD, which begin to resolve within 2 hours. In this optimally treated cohort, regular high-intensity interval training did not produce a sustained anti-inflammatory effect. REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT04268992.
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