Evidence map›Paper›PMID 41631551›Full record

ArticleActa ophthalmologica2026

Retinal oxygen saturation and retinal vessel diameter in glaucoma patients before and after trabeculectomy.

S Kemp, A Ahmadzadeh, B Schmidt, O N Klefter, L Kessel, D Bach-Holm

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Article in Acta ophthalmologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

S KempDepartment of Ophthalmology, Copenhagen University Hospital-Rigshospitalet-Glostrup, Glostrup, Denmark.
A AhmadzadehDepartment of Ophthalmology, Copenhagen University Hospital-Rigshospitalet-Glostrup, Glostrup, Denmark.
B SchmidtDepartment of Ophthalmology, Copenhagen University Hospital-Rigshospitalet-Glostrup, Glostrup, Denmark.
O N KlefterDepartment of Ophthalmology, Copenhagen University Hospital-Rigshospitalet-Glostrup, Glostrup, Denmark.
L KesselDepartment of Ophthalmology, Copenhagen University Hospital-Rigshospitalet-Glostrup, Glostrup, Denmark.
D Bach-HolmDepartment of Ophthalmology, Copenhagen University Hospital-Rigshospitalet-Glostrup, Glostrup, Denmark.

Funding

Aase og Ejnar Danielsens FondFabrikant Einar Willumsens FondFight for Sight DenmarkGangsted FondHenry og Astrid Møllers FondSynoptik FoundationThe Danish Eye Research Foundation
6 · The paper itself

Abstract

purposeTo compare retinal vessel oxygen saturations and diameters before, 1 and 3 months after trabeculectomy.

methodsRetinal oxygen saturations and vessel diameters were obtained using retinal oximetry. The effect of the postoperative intraocular pressure (IOP) decrease on the arteriovenous difference (AV-difference) was evaluated, adjusting for mean defect (MD). The impact of trabeculectomy on AV-difference was compared between lowest (Q1) and highest (Q4) MD quartiles. Paired t-test, linear regression and Welch's t-test were applied.

resultsOf 72 enrolled participants, 64 eyes of 64 participants were included. Arteriolar oxygen saturations were unchanged (97.4 ± 4.9% preoperatively, 98.1 ± 6.0% 1 month [p = 0.053], 98.2 ± 6.8% 3 months postoperatively [p = 0.154]). Venular saturations were also unchanged (62.0 ± 9.5% preoperatively, 61.7 ± 8.0% 1 month [p = 0.505], 61.3 ± 10.6% 3 months postoperatively [p = 0.685]). No significant difference in AV-difference occurred. Arteriolar diameters were unchanged 1 month postoperatively (109.7 μm ± 16.2 vs. 110.9 μm ± 19.3 [p = 0.80]) but decreased to 106.0 μm ± 15.7 3 months postoperatively (p = 0.012). Venular diameters increased 1 month postoperatively (152.8 μm ± 21.3 vs. 147.7 μm ± 20.0 [p = 0.034]) but not 3 months postoperatively (148.6 μm ± 24.8; p = 0.893). No association between postoperative IOP decrease and postoperative MD-adjusted AV-difference was found (p = 0.380). No significant change in AV-difference between Q1 and Q4 (p = 0.18) was found.

conclusionRetinal oxygen saturations remained stable, whereas vessel diameter changes occurred after trabeculectomy, probably reflecting alterations in IOP and perfusion pressure.

Indexed as

GlaucomaIntraocular PressureOxygenOxygen SaturationRetinal VesselsTrabeculectomyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedOximetryPostoperative PeriodProspective StudiesOxygenarteriovenous differenceglaucomaoximetryretinal vessel diameterretinal vessel oxygenationtrabeculectomy

Identifiers

PMID41631551
PMCPMC13353620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.