ArticleBasic & clinical pharmacology & toxicology2026
Subchronic Exposure to Aripiprazole Subtly Impacts on Rodents' Sperm Quality and Fertility.
Article in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Sterol biosynthesis, brain development, and disease.The Journal of clinical investigation · 2026Review
- Subchronic Exposure to Aripiprazole Subtly Impacts on Rodents' Sperm Quality and Fertility.Basic & clinical pharmacology & toxicology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Aripiprazole, a third-generation antidepressant/antipsychotic drug, acts on serotonergic and dopaminergic receptors and is widely prescribed for mental disorders, such as depression and schizophrenia. Studies indicate that this class of drugs can impact directly on sperm quality and fertility. Then, this study evaluated the effects of subchronic exposure to aripiprazole on sperm quality and fertility of adult male Wistar rats. Thirty-six rats were divided into three groups: control, 3 mg/kg and 6 mg/kg of aripiprazole orally exposed for 28 days. Our results showed that aripiprazole significantly increased seminal vesicle weight at a dose of 6 mg/kg. Progressive sperm motility was reduced, and there was an increase in the diameter of the seminiferous tubules at a dose of 3 mg/kg. Fertility test was reduced at a dose of 6 mg/kg. These findings suggest that although aripiprazole is effective in treating mental disorders, it may have subtle adverse effects on reproduction, especially on sperm quality and fertility, raising concerns about its indiscriminate use at doses higher than those tested.
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Registered trials
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