ReviewThe journal of allergy and clinical immunology. Global2025
Mutations of
Review in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From acute mast cell activation to a structured immunothrombotic and autoimmune niche in chronic spontaneous urticaria.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Advances in MRGPRX2-mediated anaphylactoid reactions to traditional Chinese medicine injections.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mast cells (MCs) express the novel class A Mas-related G protein-coupled receptor X2 (MRGPRX2). Additionally, neurons and other leukocytes including basophils express MRGPRX2. MC activation dependent on IgE is a well-established and extensively researched mechanism of type I hypersensitivity and allergic reactions. It was not until MRGPRX2 was identified as the receptor in charge of pseudo-allergy or IgE-independent MC activation that non-IgE-mediated MC degranulation was defined and acknowledged, despite the known clinical phenotype of "pseudo-allergy." The identification and characterization of MRGPRX2 subsequently solved the enigma of non-IgE-mediated (pseudo-allergic) response. Studies indicate that MRGPRX2 is involved in the manifestation of symptoms in atopic dermatitis, neurogenic inflammation, and chronic urticaria. In 2021, it was reported that naturally occurring missense mutations in the
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.