ArticleCureus2025
Seropositivity of Transfusion-Transmissible Infections Among Blood Donors in the Eastern Zone of Tanzania During the Early COVID-19 Period: A Cross-Sectional Analysis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- [Special aspects of magnetic resonance imaging of pediatric bone marrow].Radiologie (Heidelberg, Germany) · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Transfusion-transmissible infections (TTIs), such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis, remain critical threats to blood safety in many low and middle-income countries. The COVID-19 pandemic has disrupted blood donation activities globally, raising concerns about its impact on donor screening outcomes. This study assessed TTI seropositivity among blood donors in the Eastern Zone of Tanzania during the early COVID-19 period. Methods A retrospective cross-sectional analysis was conducted using donor records collected between January and July 2020 at the Eastern Zone of the Blood Transfusion Centre. Screening adhered to the national and WHO-recommended algorithms using chemiluminescent immunoassays. Donor characteristics and TTI prevalence were summarized descriptively. Logistic regression was used to identify factors associated with HBV seropositivity, as hepatitis B had the highest prevalence and sufficient event counts to support stable multivariable analysis compared with other TTIs. Results Among 16,767 donors with complete records, 1,774 (10.7%) tested positive for at least one TTI. HBV was the most frequent infection (897, 5.4%), followed by syphilis (453, 2.7%), HIV (311, 1.9%), and HCV (207, 1.2%). Coinfections were rare: HBV-HIV (35, 0.21%), HBV-syphilis (27, 0.16%), and HBV-HCV (15, 0.09%). Blood collection volumes decreased sharply in April-May 2020 but recovered by July. Monthly HBV and TTI seroprevalence showed stable descriptive trends (4.1-6.1%), with no apparent increase during low-donation months. Independent predictors of HBV seropositivity included male sex (AOR 1.7, 95% CI 1.4-2.3) and age 30-39 years (AOR 3.2, 95% CI 2.1-4.8). Conclusion Despite disruptions in blood collection, TTI seroprevalence remained stable during the early COVID-19 period, suggesting resilience in donor selection and screening procedures. Strengthening donor recruitment and maintaining rigorous laboratory screening remain essential to safeguard the blood supply in Tanzania.
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