Evidence map›Paper›PMID 41631195›Full record

ArticleNature. Mental health2026

Interaction between Neighborhood Exposome and Genetic Risk in Child Persistent Distressing Psychotic-like Experiences.

Yinxian Chen, Qingyue Yuan, Lina Dimitrov, Benjamin Risk, Benson Ku, Anke Huels

Abstract read
In one paragraph

Article in Nature. Mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Yinxian ChenDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Qingyue YuanDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Lina DimitrovDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Benjamin RiskDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Benson KuDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Anke HuelsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Funding

Air pollution and early signs of dementiaR01AG079170 · NIA · EMORY UNIVERSITY · PI Anke Huels, Thomas Spurgeon Wingo · 2022 to 2026
$3.6M
Statistical approaches to improving functional connectivity estimates with an application to autismR01MH129855 · NIMH · EMORY UNIVERSITY · PI Benjamin Brewster Risk · 2022 to 2026
$3.5M
Impact of Neighborhood Characteristics on Conversion to Psychosis among Youth at Clinical High Risk for PsychosisK23MH129684 · NIMH · EMORY UNIVERSITY · PI Benson Ku · 2022 to 2026
$970k
NIA NIH HHS R01 AG079170NIMH NIH HHS K23 MH129684NIMH NIH HHS R01 MH129855
6 · The paper itself

Abstract

The genetic risk of persistent distressing psychotic-like experiences (PLE) in the multi-ancestral population is under-investigated. The gene-neighborhood environment interaction in persistent distressing PLE is also unknown. This study included 6,449 participants from the Adolescent Brain and Cognitive Development Study. Genetic risk was measured by a multi-ancestral schizophrenia polygenic risk score (SCZ-PRS). Multi-dimensional neighborhood-level exposures were used to form the neighborhood exposome (NE). SCZ-PRS was not statistically significantly associated with odds of persistent distressing PLE (OR = 1.04, 95% CI: 0.97, 1.13,

Identifiers

PMID41631195
PMCPMC12861328

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.