Evidence map›Paper›PMID 41631172›Full record

ArticleJournal of cardiology cases2025

Angioedema presumably caused by hypersensitivity reactions to pacemaker implantation.

Naoshi Ito, Shusuke Yagi, Tomoko Takahashi, Yutaka Kawabata, Kazuki Tezuka, Tomomi Matsuura, Muneyuki Kadota, Takayuki Ise, Koji Yamaguchi, Hirotsugu Yamada and 2 more

Abstract readCase Reports
In one paragraph

Article in Journal of cardiology cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Naoshi ItoThe Post-graduate Education Center, Tokushima University Hospital, Tokushima, Japan.
Shusuke YagiDepartment of General Medicine, Tokushima University Hospital, Tokushima, Japan.
Tomoko TakahashiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Yutaka KawabataDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Kazuki TezukaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Tomomi MatsuuraDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Muneyuki KadotaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Takayuki IseDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Koji YamaguchiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Hirotsugu YamadaDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Takeshi SoekiDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.
Masataka SataDepartment of Cardiovascular Medicine, Tokushima University Hospital, Tokushima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal allergies, including hypersensitivity to medical devices, are thought to have decreased with the increasing number of medical devices made of titanium. However, cases of angioedema as well as local reactions have been reported after implantation of cardiovascular implantable electronic devices in patients. We report the case of a man in his 80s who experienced left arm swelling after pacemaker implantation 10 years previously, experienced recurrence of left arm swelling, and was diagnosed with angioedema after pacemaker battery exchange. Angioedema should be listed as a differential diagnosis for edema of the arm in patients implanted with implantable cardiovascular electronic devices. Learning objective: Angioedema due to metal allergies should be listed as a differential diagnosis for edema of the arm in patients implanted with implantable cardiovascular electronic devices even in a pacemaker implanted 10 years previously.

Indexed as

Cardiovascular implantable electronic devicesMetal allergiesTitanium

Identifiers

PMID41631172
PMCPMC12861691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.