ArticleClinical and translational radiation oncology2026
Prospective evaluation of liver cancer volumes on non-contrast 1.5 T MR Linac imaging.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The 1.5 T MR-Linac (MRL) provides a platform for online adaptive stereotactic body radiation therapy (SBRT). This study aims to compare gross tumor volume (GTV) on multiphasic (MP) CT and MR simulation imaging versus non-contrast MRL images and to measure changes in GTV during SBRT. Methods: Primary or metastatic liver cancer patients treated with SBRT using MRL or cone beam CT (CBCT) were eligible for this prospective imaging study. At simulation, patients underwent MP CT and MP 3 T MR liver T1-weighted (T1w) imaging in exhale breath hold and T2-weighted (T2w) images on 1.5 T MRL (MRL0). Repeat MRL T2w images were acquired at each SBRT fraction. Liver tumors were contoured on simulation CT/MR and MRL0 images and on each subsequent MRL image. MRL0 GTV were compared to MP CT/MR GTV and changes during SBRT were measured. Results: From August 2019 to January 2023, 29 liver tumors (23 patients) treated with SBRT, were contoured on 23 MP CT/3T MR and 103 MRL imaging datasets. Simulation MRL0 interquartile median GTV was 43.3 cc (IQR 4.3-47.7 cc), GTV on MRL0 images were smaller than MP CT/3T MR volumes by an average of 7.1 cc (95 % CI 1.9-12.2, p = 0.008) or 21.9 % (95 % CI 13.5-30.2, p = <0.001). Over the course of SBRT there were no statistically significant predictable trends in tumor volume. Conclusion: GTV based on MRL T2w images were significantly smaller than GTV based on MP CT/3T MR images. This systematic difference should be considered during adaptive MRL liver SBRT. There were no predictable changes in tumor volumes during SBRT.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.