Chinese traditional medicine complex hemorrhoidal analgesic cream promotes wound healing in diabetic rats after anal fistula surgery via Keap1/Nrf2 signaling pathway.

Jian Liu, Zhitao Yin, Xiaojun Tian, Delong Liu, Chunxiao Wang, Hexue Yuan

Abstract read

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Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Jian LiuThe Gastrointestinal and Anorectal Hospital of Shenyang, Shenyang Campus, Liaoning, 110002, China.

Zhitao YinThe Gastrointestinal and Anorectal Hospital of Shenyang, Shenyang Campus, Liaoning, 110002, China.

Xiaojun TianShenyang Second Hospital of Traditional Chinese Medicine, Liaoning, 110101, China.

Delong LiuThe Gastrointestinal and Anorectal Hospital of Shenyang, Shenyang Campus, Liaoning, 110002, China.

Chunxiao WangThe Gastrointestinal and Anorectal Hospital of Shenyang, Shenyang Campus, Liaoning, 110002, China.

Hexue YuanThe Gastrointestinal and Anorectal Hospital of Shenyang, Shenyang Campus, Liaoning, 110002, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study to elucidate how hemorrhoidal analgesic cream (HAC), grounded in the traditional Chinese medicine (TCM) 'elevation and causation' theory, promotes postoperative wound healing after anal fistula surgery in diabetic rats by modulating the Keap1/Nrf2 signaling pathway. We used high-sugar and high-fat chow combined with streptozotocin (STZ) to induce diabetic rats to establish a postoperative wound model of anal fistula. The rats were divided into a blank control group, model group, wound-only group, experimental group (HAC treatment), and positive control group (recombinant human epidermal growth factor gel). HAC's impact on wound healing was evaluated by glycated hemoglobin (HbA1c), serum inflammatory factors (TNF-α, IL-6), oxidative stress markers (SOD, MDA), and Nrf2 pathway proteins and mRNA. The results showed that the wound healing rate was significantly increased in the HAC group (92.85 ± 3.41 %,

Indexed as

Diabetic anal fistulaHemorrhoidal analgesic creamInflammationKeap1/Nrf2 signaling pathwayOxidative stressWound healing

Identifiers

PMID41630980

DOI10.1016/j.bbrep.2025.102258

PMCPMC12861702

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.