Evidence map›Paper›PMID 41630937›Full record

ArticlePaediatrics & child health2026

Oral morphine pharmacokinetics in healthy children and the effect of genetic polymorphisms: An exploratory study.

Lauren Faught, Abdelbaset A Elzagallaai, Nicholas Tonial, Samina Ali, Natasha Lepore, Jaime Reardon, Brad Urquhart, Colin Ross, Michael J Rieder, Naveen Poonai

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Article in Paediatrics & child health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lauren FaughtDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.
Abdelbaset A ElzagallaaiDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.
Nicholas TonialDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, Ontario.
Samina AliDepartment of Paediatrics, Stollery Women's and Children's Hospital, Edmonton, Alberta.ORCID https://orcid.org/0000-0002-0595-364X
Natasha LeporeDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.
Jaime ReardonDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.
Brad UrquhartDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.ORCID https://orcid.org/0000-0001-8324-1472
Colin RossFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia.ORCID https://orcid.org/0000-0003-1476-7037
Michael J RiederDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.
Naveen PoonaiDepartments of Paediatrics and Epidemiology & Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario.ORCID https://orcid.org/0000-0003-1540-0413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To explore the pharmacokinetics of oral morphine and the potential effect of pharmacogenetics on efficacy and safety in children. Methods: Serial blood samples were obtained from healthy children aged 5-17 years. We determined morphine, morphine-6-glucoronide (M6G) and morphine-3-glucoronide (M3G) concentrations and pharmacokinetic parameters. We performed genotyping and collected pain scores. Results: A total of 13 children received a single dose of oral morphine 0.5 mg/kg. For morphine, M6G, and M3G, median T Conclusions: Oral morphine's active metabolites have a longer t

Indexed as

Drug safetyOral morphinePharmacogenomicsPharmacokinetics

Identifiers

PMID41630937
PMCPMC12861532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.