Evidence map›Paper›PMID 41630919›Full record

ArticleiScience2026

Circadian

Cynthia Tchio, Matthew Maher, Christopher Moth, Jens Meiler, Jacqueline M Lane, Herman A Taylor, Jonathan S Williams, Richa Saxena

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

8 authors.

Cynthia TchioCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Matthew MaherCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Christopher MothInstitute for Drug Discovery, Faculty of Medicine, Faculty of Mathematics and Informatics, Faculty of Chemistry and Mineralogy, University Leipzig, Leipzig, Germany.
Jens MeilerInstitute for Drug Discovery, Faculty of Medicine, Faculty of Mathematics and Informatics, Faculty of Chemistry and Mineralogy, University Leipzig, Leipzig, Germany.
Jacqueline M LaneCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Herman A TaylorCardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA.
Jonathan S WilliamsDepartment of Medicine Endocrinology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Funding

Decrypting Variants of Uncertain Significance in Long-QT SyndromeR01HL122010 · NHLBI · VANDERBILT UNIVERSITY · PI GEORGE, ALFRED L., SANDERS, CHARLES R · 2014 to 2025
$15.5M
Genetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0M
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8M
Dissecting Causal Role of Insomnia in Cardiovascular DiseaseR01HL146751 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MELKANI, GIRISH C., SAXENA, RICHA · 2020 to 2023
$3.6M
Leveraging human genetics to overcome complex diagnostic challenges, evaluation of pan-ancestry polygenic scores to reduce misdiagnosis of narcolepsy and circadian rhythm sleep wake disorders.R01HG012810 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI Daniel J Gottlieb · 2023 to 2026
$2.6M
Structural Determinants of Allosteric Modulation of Brain GPCRsR01DA046138 · NIDA · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2019 to 2023
$2.0M
Cerebrovascular involvement in Alzheimer's Disease: PAR4 AntagonismR01AG068623 · NIA · VANDERBILT UNIVERSITY · PI HAMM, HEIDI E, MEILER, JENS · 2024 to 2025
$1.4M
Personalized Structural Biology: Enabling Exome Interpretation in Undiagnosed DiseasesR01LM013434 · NLM · VANDERBILT UNIVERSITY · PI CAPRA, JOHN ANTHONY, MEILER, JENS · 2021 to 2024
$1.4M
Genetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848k
GPU-Accelerated Parallel Computer for Life Sciences ResearchS10OD032234 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2022 to 2022
$600k
Parallel Computer with High Memory NodesS10OD016216 · OD · VANDERBILT UNIVERSITY · PI PISTON, DAVID W · 2013 to 2013
$598k
GPU-Accelerated Parallel Computer for Drug Discovery ApplicationsS10OD020154 · OD · VANDERBILT UNIVERSITY · PI SMITH, JARROD ANSON · 2015 to 2015
$225k
NHGRI NIH HHS R01 HG012810NHLBI NIH HHS K01 HL136884NHLBI NIH HHS R01 HL122010NHLBI NIH HHS R01 HL146751NIA NIH HHS R01 AG068623NIDA NIH HHS R01 DA046138NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK107859NIH HHS S10 OD016216NIH HHS S10 OD020154NIH HHS S10 OD032234NLM NIH HHS R01 LM013434
6 · The paper itself

Abstract

Modern lifestyles often disturb circadian rhythms, yet the genetic circuits that convert this stress into metabolic dysfunction remain poorly defined. Here, we identify a missense variant in

Indexed as

GenomicsHuman metabolism

Identifiers

PMID41630919
PMCPMC12860998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.