Evidence map›Paper›PMID 41630915›Full record

ArticleiScience2026

Commensal human gut microbes produce species specific neuroactive compounds.

Anna M Tingler, Charulekha Packirisamy, Alyssa Gutierrez, Adelaide E Horvath, Makenna Grozis, Sigmund J Haidacher, Kathleen M Hoch, Anthony M Haag, Numan Oezguen, Kristen A Engevik and 3 more

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna M TinglerDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Charulekha PackirisamyDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Alyssa GutierrezDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Adelaide E HorvathDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Makenna GrozisDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Sigmund J HaidacherDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Kathleen M HochDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Anthony M HaagDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Numan OezguenDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Kristen A EngevikDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Amy C EngevikDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.
Thomas D HorvathDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Melinda A EngevikDepartment of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, USA.

Funding

Tissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3M
Proteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DON C. ROCKEY · 2020 to 2026
$8.8M
Cellular, Biochemical and Molecular Sciences Training Program: Developing the skills and expertise needed for a changing biomedical landscapeT32GM132055 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Amy D Bradshaw, John P O'Bryan · 2019 to 2026
$3.9M
Digestive Disease Training ProgramT32DK124191 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI STEPHEN A DUNCAN, Antonis Kourtidis · 2021 to 2026
$1.0M
Novel Tools to Investigate Local and Global RNA Conformations in the SpliceosomeR00GM120457 · NIGMS · UNIVERSITY OF OREGON · PI WIDOM, JULIA REED · 2019 to 2021
$747k
The role of Myosin Vb in Hepatocyte Protein TraffickingK01DK121869 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ENGEVIK, AMY C · 2019 to 2023
$669k
Identifying the role of serotonin receptor 4 and trefoil factor 3 in intestinal wound repairK01DK123195 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI ENGEVIK, MELINDA ANNE · 2020 to 2024
$612k
ACQUISITION OF A QTRAP 7500 HYBRID QQQ/LIT MASS SPECTROMETER FOR PEDIATRIC TRANSLATIONAL RESEARCHS10OD036416 · OD · BAYLOR COLLEGE OF MEDICINE · PI HORVATH, THOMAS DONALD · 2024 to 2024
$598k
Novel tools to investigate local and global RNA conformations in the spliceosomeK99GM120457 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WIDOM, JULIA REED · 2016 to 2017
$180k
NIDDK NIH HHS K01 DK121869NIDDK NIH HHS K01 DK123195NIDDK NIH HHS P30 DK056338NIDDK NIH HHS P30 DK123704NIDDK NIH HHS T32 DK124191NIGMS NIH HHS K99 GM120457NIGMS NIH HHS R00 GM120457NIGMS NIH HHS T32 GM132055NIH HHS S10 OD036416
6 · The paper itself

Abstract

The gut microbiota communicates with multiple organs through neuroactive molecules, but the specific compounds produced remain unclear. We investigated eight commensal gut species,

Indexed as

biological sciencesmicrobiologynatural sciences

Identifiers

PMID41630915
PMCPMC12860712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.