ArticlePeerJ2026
Sperm chromatin condensation defects and IVF outcomes: a retrospective cohort study.
Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The seminal plasma sTLR4/IL-1β ratio as an independent factor associated with sperm chromatin condensation defects.Frontiers in physiology · 2026Article
- Age-related differences in sperm chromatin packaging and protein profiles based on SDS-PAGE in Bali bulls (Journal of advanced veterinary and animal research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The clinical impact of sperm chromatin condensation defects (SCCD) on Methods: This retrospective cohort study included 647 couples. Multivariable logistic regression was used to evaluate associations between SCCD (assessed by aniline blue staining) and clinical outcomes, with stratification and generalized additive models employed to identify effect modifiers and nonlinear relationships. Results: Elevated SCCD levels (≥30%) were correlated with abnormal conventional semen parameters and a reduced two-pronuclei (2PN) cleavage rate, whereas no significant associations were observed with spontaneous abortion, gestational age, birth weight, or neonatal sex distribution. After adjusting for key confounders, increasing SCCD levels remained independently associated with reduced clinical pregnancy (OR = 0.98, Conclusions: This study provides evidence that SCCD is independently associated with reduced IVF success, supporting its assessment in pre-IVF evaluation.
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What OpenQuestion holds
Registered trials
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