Evidence map›Paper›PMID 41630747›Full record

ArticleOpen veterinary journal2025

Protective effect of Spirulina and

Fady E AbdelKhalek, Elsayed Abdel-Aziz, Gamal Shams, Abdelalim Fouad, Sameh Elnabtity, Wageh Sobhy Darwish

Abstract read
In one paragraph

Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Ameliorative Effects ofFoods (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fady E AbdelKhalekDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Elsayed Abdel-AzizDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Gamal ShamsDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Abdelalim FouadDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Sameh ElnabtityDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Wageh Sobhy DarwishDepartment of Food Hygiene, Safety and Technology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Betamethasone (BM) is a long-acting synthetic fluorinated glucocorticoid with metabolic, immunosuppressive, anti-inflammatory, and anti-proliferative effects. However, its use is associated with adverse effects, particularly on the liver and kidneys. Aim: This study aimed to investigate the protective effect of Spirulina and Lagenaria siceraria against bone marrow-induced adverse effects in rats. Methods: Sixty male Wistar albino rats were divided into six groups and treated for three successive weeks. The control group received distilled water orally on a daily basis water daily, the BM group, BM and Spirulina group, BM and Results: BM caused a significant increase in serum urea, uric acid, and creatinine levels. Liver function was disturbed as liver enzymes showed significant increases in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione triphosphate (GGT), and decreased total protein, albumin, and globulin. Sodium, potassium, and calcium levels significantly decreased. The lipid profiles showed an increase in HDL cholesterol, VLDL, serum cholesterol, low-density lipoprotein (LDL) cholesterol, and TGs. The oxidant and oxidant status showed an increase in MDA and a decrease in superoxide dismutase and total antioxidant capacity. Increases in the random blood glucose, insulin level (fasting), and hemostatic insulin assignment of insulin resistance, PTH, and increased TGF-β and IL6 in the liver, kidney, and spleen were also recorded. Spirulina and Conclusion: Spirulina and/or

Indexed as

BetamethasoneSpirulinaAnimalsAntioxidantsKidneyLiverMaleRatsRats, WistarAntioxidantsBetamethasoneAdverse effectsBetamethasoneLagenaria sicerariaRatsSpirulina

Identifiers

PMID41630747
PMCPMC12861458

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.