Evidence map›Paper›PMID 41630642›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Single-cell analysis reveals neuroprotective histone deacetylase inhibitor pathways.

Madeline Peyton, Nur Jury-Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D McCabe, Timothy I Richardson, Kun Huang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Single-cell analysis reveals neuroprotective histone deacetylase inhibitor pathways.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Madeline PeytonDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.ORCID 0009-0004-3921-5663
Nur Jury-GarfeDepartment of Anatomy, Cell Biology & Physiology, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Jiahui LiuDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Caleb BeimfohrDepartment of Medicine, Division of Clinical Pharmacology, School of Medicine, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Chitra SunilDepartment of Environmental & Public Health Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Steven BrooksDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Pengyue ZhangDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Sean D McCabeDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Timothy I RichardsonIndiana Biosciences Research Institute, Indianapolis, Indiana, USA.
Kun HuangDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Cristian A Lasagna-ReevesDepartment of Anatomy, Cell Biology & Physiology, Indiana University Indianapolis, Indianapolis, Indiana, USA.
Jie ZhangIndiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana, USA.
Travis S JohnsonDepartment of Biostatistics and Health Data Science, Indiana University Indianapolis, Indianapolis, Indiana, USA.

Funding

Structural Biology CoreU54AG065181 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Timothy I Richardson · 2019 to 2026
$61.3M
The Indiana Training Program in Public & Population Health InformaticsT15LM012502 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI Brian E. Dixon, William F Fadel · 2017 to 2026
$4.7M
DMS/NIGMS 1: Topological Study on Histological Images and Spatial TranscriptomicsR01GM148970 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI CHEN, CHAO, JOHNSON, TRAVIS STEELE · 2022 to 2024
$682k
A deep-transfer-learning framework to transfer clinical information to single cells and spatial locations in cancer tissuesR21CA264339 · NCI · INDIANA UNIVERSITY INDIANAPOLIS · PI JOHNSON, TRAVIS STEELE, ZHANG, JIE · 2022 to 2023
$394k
NCI NIH HHS 1R21CA264339NCI NIH HHS R21 CA264339NIA NIH HHS U54 AG065181NIA NIH HHS U54AG065181NIGMS NIH HHS R01 GM148970NIH HHS 1R01GM148970NLM NIH HHS T15 LM012502NLM NIH HHS T15LM012502
6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) involves β-amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease-modifying therapies remain elusive. We integrated single-cell RNA sequencing (scRNA-seq), spatial transcriptomics, and in vitro validation to identify repurposable drugs for AD

methodsComputational drug repurposing was performed using cell-type-specific analysis of scRNA-seq datasets from AD cortical regions. Trichostatin-A (TSA) effects were validated in human induced pluripotent stem cells (iPSC) -derived cortical neurons exposed to Aβ oligomers. Cross-dataset integration identified convergent therapeutic targets.

resultsTSA emerged as the top candidate, protecting neurons from Aβ toxicity and preserving synaptic integrity. DISC1 (Disrupted-In-Schizophrenia 1) was uniquely upregulated across TSA-treated neurons, AD-associated neuronal subpopulations, and protective microglial subtypes. DISCUSSION: DISC1 represents a convergent therapeutic target for AD, mediating TSA's neuroprotective effects through pathways regulating GSK3β, mitochondrial transport, and synaptic plasticity, providing a mechanistic framework for developing AD therapeutics.

Indexed as

Alzheimer DiseaseHistone Deacetylase InhibitorsHydroxamic AcidsNeuronsNeuroprotective AgentsSingle-Cell AnalysisAmyloid beta-PeptidesDrug RepositioningHumansInduced Pluripotent Stem CellsNerve Tissue ProteinsAmyloid beta-PeptidesDISC1 protein, humanHistone Deacetylase InhibitorsHydroxamic AcidsNerve Tissue ProteinsNeuroprotective Agentstrichostatin AADAlzheimer's diseaseamyloid‐betaDISC1drug repurposingHDAChistone deacetylase inhibitormicroglianeuroinflammationneuroprotectionscRNA‐seqsingle‐cell RNA sequencingtrichostatin‐ATSA

Identifiers

PMID41630642
PMCPMC12865332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.