ArticleAngewandte Chemie (International ed. in English)2026
Development of PolyHis-Targeting PROTAC Degraders.
Hui Chen, Dong Zhu, Monica Billitti, Annan Sun, Lingtao Jin, Emily Moser, Nahid F Mivechi, Guangrong Zheng, Dongwen Lv
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In one paragraphArticle in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Hui ChenDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Dong ZhuGeorgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Monica BillittiGeorgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Annan SunDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Lingtao JinDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, Texas, USA.
Emily MoserDepartment of Pulmonary, Critical Care and Sleep Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.
Nahid F MivechiGeorgia Cancer Center, Augusta University, Augusta, Georgia, USA.
Guangrong ZhengDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-8106-6663 Funding
Inhibition of Bcl-xL by Targeted DegradationR01CA241191 · NCI · UNIVERSITY OF FLORIDA · PI KONOPLEVA, MARINA Y, ZHENG, GUANGRONG · 2020 to 2024
$2.6MOrbitrap Exploris 480 Mass Spectrometer for Biomedical ResearchS10OD030371 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI WEINTRAUB, SUSAN T · 2022 to 2022
$882kHijacking Post-translational Arginylation for Targeted Protein DegradationR21CA292191 · NCI · WASHINGTON UNIVERSITY · PI LIN, ZONGTAO, LYU, DONGWEN · 2024 to 2024
$426kDevelopment of Caspase Cleavage Targeting Chimeras (CACTACs) for Targeted Protein Cleavage.R21CA286307 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LYU, DONGWEN · 2024 to 2025
$409kNCI NIH HHS R01 CA241191NCI NIH HHS R21 CA286307NCI NIH HHS R21 CA292191NIH HHS R01 CA241191NIH HHS R21 CA286307NIH HHS R21 CA292191NIH HHS S10 OD030371NIH HHS S10 OD030371-01A1
6 · The paper itselfAbstract
Targeted protein degradation (TPD) via proteolysis targeting chimeras (PROTACs) enables selective removal of proteins of interest (POIs) by hijacking the ubiquitin-proteasome system (UPS). However, broad application is constrained by the availability of high-quality target ligands, which remain scarce for much of the human proteome, limiting assessment of POIs for UPS-mediated degradation. To address this challenge, we developed polyhistidine-targeting PROTACs (polyHisTACs) by conjugating a nickel-nitrilotriacetic acid (Ni
Indexed as
HistidineProteolysis Targeting ChimeraAdaptor Proteins, Signal TransducingBromodomain Containing ProteinsCell Cycle ProteinsHumansNickelNitrilotriacetic AcidOrganometallic CompoundsProteasome Endopeptidase ComplexProteolysisRNA-Binding ProteinsTranscription FactorsUbiquitin-Protein LigasesVon Hippel-Lindau Tumor Suppressor ProteinAdaptor Proteins, Signal TransducingBRD4 protein, humanBromodomain Containing ProteinsCell Cycle ProteinsCRBN protein, humanHistidineNickelnickel nitrilotriacetic acidNitrilotriacetic AcidOrganometallic CompoundspolyhistidineProteasome Endopeptidase ComplexProteolysis Targeting ChimeraPSPC1 protein, humanRNA-Binding ProteinsTranscription FactorsUbiquitin-Protein LigasesVHL protein, humanVon Hippel-Lindau Tumor Suppressor ProteinHiBiTpolyhistidinePROTACtargeted protein degradation
Identifiers
PMID41630184
PMCPMC12997399
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