Evidence map›Paper›PMID 41630111›Full record

ArticleMolecular horticulture2026

The genome of the medicinal plant Uncaria rhynchophylla provides new insights into monoterpenoid indole alkaloid metabolism and its molecular regulatory mechanism.

Detian Mu, Lingyun Wan, Yingying Shao, Limei Pan, Xinghui Liu, Iain W Wilson, Zhixing Qing, Yu Zhou, Ying Lu, Yingjie He and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular horticulture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Detian Mu *College of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China.
Lingyun Wan *Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, 530023, China.
Yingying Shao *College of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China.
Limei Pan *Guangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, 530023, China.
Xinghui LiuCollege of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China.
Iain W WilsonCSIRO Agriculture and Food, Canberra, ACT 2601, Australia.
Zhixing QingCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Yu ZhouCollege of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China.
Ying LuCollege of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China.
Yingjie HeSouthern University of Science and Technology, Shenzhen, 518055, China.
Lina ZhuCollege of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China.
Jine FuGuangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, 530023, China.
Shugen WeiGuangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, 530023, China. weishugen2@163.com.
Xiaojun MaGuangxi Key Laboratory of High-Quality Formation and Utilization of Dao-di Herbs, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, 530023, China.
Chi SongWuhan Benagen Technology Company Ltd., Wuhan, 430075, China. songchi@benagen.com.
Deyou QiuState Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, 100091, China.
Qi TangCollege of Horticulture, National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Yuelushan Lab, Hunan Agricultural University, Changsha, 410128, China. tangqi@hunau.edu.cn.ORCID http://orcid.org/0000-0003-2385-4263

Funding

National Natural Science Foundation of China 81903752National Natural Science Foundation of China 82360753the Interdisciplinary Research Youth Guidance Project of Hunan Agricultural University No.2024XKJC02
6 · The paper itself

Abstract

The high-quality chromosomal-level genome assembly (627.72 Mb, contig N50 1.80 Mb) of Uncaria rhynchophylla, a Chinese herb used for hypertension and Alzheimer's disease. Integrated genomic and transcriptomic analyses identified 46,909 genes, including 72 UrWRKY transcription factors. Sixty-four candidate genes for monoterpenoid indole alkaloid (MIA) biosynthesis were screened. Functional validation confirmed UrTDC6 catalyzes tryptamine formation and UrLAMT1/UrLAMT2 catalyze loganin production. Correlation analysis linked MIA content with UrWRKY expression, identifying UrWRKY37 as a key regulator. UrWRKY37 directly activates UrTDC and UrSGD transcription. Overexpression in hairy roots upregulated MIA pathway genes and significantly increased accumulation of isocorynoxeine, corynoxeine, and isorhynchophylline. This work elucidates MIA biosynthesis and its transcriptional regulation in U. rhynchophylla.

Indexed as

GenomeMIA biosynthesisSecondary metabolismTranscription factorUncaria rhynchophylla

Identifiers

PMID41630111
PMCPMC12866418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.