Observational studyJournal of the Chinese Medical Association : JCMA2026
Change in dapagliflozin trial eligibility status and prognosis among patients with acute heart failure with preserved ejection fraction.
Observational study in Journal of the Chinese Medical Association : JCMA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisease-modifying therapy for heart failure with preserved ejection fraction (HFpEF) remains limited. The Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (DELIVER) trial demonstrated the benefits of disease‑modifying therapy and outlined the eligibility criteria for this treatment. The present study investigated how often treatment eligibility changes after hospitalization for acute decompensation and whether eligibility at discharge influences 1-year outcomes.
methodsThis single-center observational cohort study included adults hospitalized for acute HFpEF (left ventricular ejection fraction ≥50%) between January 2020 and December 2022. Elevated N‑terminal pro‑B‑type natriuretic peptide and structural heart disease (left atrial enlargement or left ventricular hypertrophy) indicated predischarge DELIVER eligibility. Eligibility was reassessed in event‑free survivors at 1-year follow-up. Primary (all-cause mortality) and secondary (cardiovascular mortality and hospitalization for heart failure [HHF]) outcomes were analyzed over a 1-year period. Kaplan-Meier and Cox analyses with stepwise adjustment were performed.
resultsOf 385 patients (mean age: 83.7 ± 13.9 years; men, 53%), 79.2% were DELIVER‑eligible at discharge. Within 1 year, 41.7% of patients who were initially ineligible became eligible, and 85.4% of patients who were eligible remained eligible. The main factor contributing to these changes was progressive left atrial dilatation. Follow-up assessments revealed 35, 20, and 68 HHFs, cardiovascular deaths, and all-cause deaths, respectively. Although eligible patients exhibited high rates of crude 1-year mortality (hazard ratio: 2.43; 95% CI, 1.11-5.30) and cardiovascular mortality and HHFs (hazard ratio: 2.83; 95% CI, 1.13-7.09) than did ineligible patients, no differences in event-free survival rates were observed after adjustment for age, sex, and comorbidities.
conclusionAlthough most patients with decompensated HFpEF met the DELIVER criteria, 41.7% of initially ineligible patients became eligible after 1 year. However, no differences were observed in the adjusted 1-year rate of all-cause mortality or cardiovascular mortality and HHFs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.