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ArticlePilot and feasibility studies2026

Engagement of coMmunity through Participatory learning and action for cOntrol and preVEntion of Type 2 Diabetes and its Risk factors (EMPOWER-D): protocol for a feasibility cluster randomised controlled trial in urban Pakistan.

Sara Imtiaz, Rubia Zafar, Amber Tahir, Mariam Abdeali, Farrukh Ahmed, Amna Mansoor, Asima Khan, Asher Fawwad, Abdul Basit, Simon Walker and 8 more

Registry-linked trialAbstract read
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Article in Pilot and feasibility studies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06570057 (Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06570057 narecruitingnot on this map

Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]: Feasibility Trial in Urban Pakistan

TypeinterventionalSponsorBaqai Institute of Diabetology and EndocrinologyRan2024 to 2027Enrolled240ConditionsType II Diabetes MellitusArmsParticipatory, learning and Action (PLA) Based intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Sara Imtiaz *Department of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Rubia Zafar *Department of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Amber TahirDepartment of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Mariam AbdealiDepartment of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Farrukh AhmedDepartment of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Amna MansoorDepartment of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Asima KhanDepartment of Health Sciences, University of York, Heslington, York, UK.
Asher FawwadDepartment of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan.
Abdul BasitDepartment of Public Health, Health Promotion Foundation, Al-Ameera Center, Saddar, Karachi, Pakistan. abdulbasit@healthpromotionfoundation.org.
Simon WalkerCentre for Health Economics, University of York, Heslington, York, UK.
Saima AfaqDepartment of Health Sciences, University of York, Heslington, York, UK. saima.afaq@york.ac.uk.
Khalid RehmanInstitute of Public Health and Social Sciences, Khyber Medical University, F1 Phase-6 Rd, Phase 5 Hayatabad, Peshawar, Pakistan.
Zohaib KhanInstitute of Public Health and Social Sciences, Khyber Medical University, F1 Phase-6 Rd, Phase 5 Hayatabad, Peshawar, Pakistan.
Mona KanaanDepartment of Health Sciences, University of York, Heslington, York, UK.
Hannah Maria JenningsDepartment of Health Sciences, University of York, Heslington, York, UK.
Abdul Rahman ShahabHealthnet TPO, House# 19, Street 5, Silo Rd, Kabul, Afghanistan.
Kamran SiddiqiDepartment of Health Sciences, University of York, Heslington, York, UK.
Zia Ul HaqInstitute of Public Health and Social Sciences, Khyber Medical University, F1 Phase-6 Rd, Phase 5 Hayatabad, Peshawar, Pakistan.

Funding

National Institute of Health and Care Research (NIHR) NIHR203248
6 · The paper itself

Abstract

backgroundDiabetes is a rapidly growing non-communicable disease globally, with 360 million out of 537 million affected adults residing in urban centres in 2021. In Pakistan, the situation is alarming, with diabetes prevalence alone exceeding 28.3% in urban areas, placing significant strain on the healthcare system exacerbated by limited resources and high management costs. Due to these multidimensional challenges, there is a growing emphasis on large-scale community-based participatory interventions like Participatory Learning and Action (PLA) for the prevention and control of type 2 diabetes mellitus (T2DM) and to improve the health outcomes of people living with T2DM. Building on a successful rural intervention from Bangladesh (D-Magic), our study aims to adapt PLA for T2DM prevention and control in urban settings and assess its feasibility in the urban context of Pakistan.

methodsThe EMPOWER-D feasibility trial is a two-arm cluster randomised control trial (cRCT) with embedded economic and process evaluation, to be conducted in the urban setting of Karachi, Pakistan. Six clusters, defined as blocks with a population of 1500, will be randomly allocated (1:1) to intervention and control arms. The intervention arm will participate in an 18-month PLA intervention, which includes monthly community meetings where group members will identify, prioritise, and address issues related to T2DM and its associated risk factors. Recruitment, appropriateness, and intervention fidelity will be assessed, alongside anthropometric, biochemical, and sociodemographic data collection. The trial data will be descriptively reported for the feasibility outcomes. DISCUSSION: This EMPOWER-D feasibility trial is among the first to implement a culturally tailored PLA intervention to prevent and control T2DM in urban low- and middle-income countries (LMICs). By conducting a feasibility cRCT trial, we aim to generate critical insights into this approach's feasibility in an urban setting, informing the implementation of a future definitive trial. Addressing T2DM aligns with the Sustainable Development Goals for 2030, exploring how community-based research can empower LMICs to tackle local health risks and targets.

trial registrationThe trial is registered at Clinicaltrials.gov on 26th August 2024 [NCT06570057]. TRIAL ACRONYM: Engagement of coMmunity through Participatory learning and action for cOntrol and preVEntion of type 2 Diabetes and its Risk factors: Urban Feasibility Trial (EMPOWER-D-UFT).

Indexed as

Feasibility trialNon-communicable diseasesParticipatory Learning and ActionPreventionProtocolType 2 diabetes mellitusUrban

Identifiers

PMID41630102
PMCPMC12958735

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.