ArticleEuropean journal of medical research2026
Inflammation meets insulin resistance: the role of the CRP-triglyceride-glucose index in association with frailty among middle-aged and older adults in China.
Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChronic inflammation and insulin resistance underpin frailty; the C-reactive protein-triglyceride-glucose index (CTI) integrates these processes. We assessed the association between CTI and frailty in a nationally representative Chinese population.
methodsWe analyzed 9,555 adults aged ≥ 45 years from the nationally representative 2015 China Health and Retirement Longitudinal Study (CHARLS). Frailty was assessed using a 32-deficit frailty index (FI), computed on a 0-1 scale and multiplied by 100 for presentation (scaled from 0 to100); frailty was defined as FI ≥ 25 (equivalently ≥ 0.25).Associations were estimated using survey-weighted linear regression (FI, continuous) and survey-weighted logistic regression (frailty). Nonlinearity was examined with restricted cubic splines; where supported, segmented regression was used to identify an inflection point.
resultsEach 1-unit higher CTI was associated with a 0.71-point higher FI (95% CI 0.37-1.05; p < 0.001) and 15% higher odds of frailty (OR, 1.15; 95% CI 1.04-1.27; p = 0.006). Compared with the lowest tertile, the highest tertile had a higher FI (β, 0.91; 95% CI 0.30-1.51; p = 0.0035) and greater odds of frailty (OR, 1.22; 95% CI 1.02-1.45; p = 0.029). Spline analyses demonstrated an overall positive association; piecewise models identified a threshold near CTI ≈7.95 (null association below; positive above).
conclusionsCTI is independently associated with frailty in a population-representative cohort. Therefore, CTI-based approaches may facilitate risk stratification in aging populations, while longitudinal validation is warranted to establish prognostic value.
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