ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2026
Effects of sublingual immunotherapy for dust mite on Th 17 / Treg cells in children with asthma.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Yiqi Guben capsule alleviates asthmatic airway inflammation through the miR-34a-5p/Notch1 pathway associated with Treg/Th17 immune balance.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Article
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6 authors.
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Abstract
objectiveobserving the clinical effects of dust mite sublingual immunotherapy (SLIT) on children with asthma, changes of Th17 / Treg cells and related cytokines in order to investigate the possible pathological mechanism of immune tolerance induced by SLIT.
methodsSixty children with asthma allergic to dust mites were included, divided into SLIT group (n = 30) and non-SLIT group (n = 30). Clinical symptoms of asthma in each group had been scored before, 1 year and 2 years after treatment. Meanwhile we also evaluated the proportion of Th17 and CD4
resultsWe found that in SLIT group, asthma symptom and drug use score, Th17 cell percentages, IL-6 and IL-17 levels have significantly decreased throughout the study period (p < 0.05), while FEV1%, Treg cell percentages and IL-10 level have prominently increased throughout the study period (p < 0.05). By contrast, in non-SLIT group, asthma symptom score, lung function, Th17 cell percentages, IL-6 and IL-17 levels have all significantly improved, but on the whole lower than SLIT group (p < 0.05). However, we have observed no statistical differences in drug use score, Treg cell percentages, IL-10 level for non-SLIT group throughout the study period.
conclusionsSLIT of Dust mite drops could change T immune cell profiles whereas improve asthma symptoms. SLIT might reverse the functional imbalance of Th 17 / Treg cells and induce immune tolerance by upregulating Treg cell function and downregulating Th17 cell function.
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