Evidence map›Paper›PMID 41630031›Full record

ArticleJournal of experimental & clinical cancer research : CR2026

AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRAS

Weiwei Li, Wenkang Yuan, Zihao Du, Xiangyu Wang, Daoyue Wang, Songlin Xing, Tingting Shen, Canliang Lu, Jiale Chen, Anhai Yu and 10 more

Abstract read
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Weiwei Li *Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Wenkang Yuan *Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Zihao Du *Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Xiangyu Wang *Department of General Surgery, Huashan Hospital Fudan University, 12th Wulumuqi Zhong Road, Jing'an District,, Shanghai, 200040, China.
Daoyue WangDepartment of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Songlin XingDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Tingting ShenClinical Pathology Center, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Canliang LuDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Jiale ChenDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Anhai YuDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Xinyu JiangDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Shiwei ZhangDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Shuhao ZhengDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Xiaowen FengInflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, 81th Meishan Road, Hefei, Anhui, 230022, China.
Tianqi WangDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China.
Jieliang ZuoDepartment of General Surgery, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
Jinhong ChenDepartment of General Surgery, Huashan Hospital Fudan University, 12th Wulumuqi Zhong Road, Jing'an District,, Shanghai, 200040, China. jinhongch@hotmail.com.
Chao ZhangDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China. chaozhang@fy.ahmu.edu.cn.
Xuefu WangInflammation and Immune Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, 81th Meishan Road, Hefei, Anhui, 230022, China. wangxuefu@ahmu.edu.cn.
Chong ZhangDepartment of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218th Jixi Road, Hefei, Anhui, 230022, China. zhangchong@fy.ahmu.edu.cn.

Funding

Inflammation and Immune Mediated Diseases Laboratory of Anhui Province IMMDL202406)National Health Commission Capacity Building and Continuing Education Center GWJJMB202510022056National Natural Science Foundation of China 82303475Quality Enhancement Project for New Era Education of Education Department of Anhui Province 2024zyxwjxalk048University Research Project of Anhui Province 2022AH040161University Research Project of Anhui Province 2025AHGXZK40773
6 · The paper itself

Abstract

backgroundThe KRAS

methodsWe screened out the differentially expressed gene Aldo-keto reductase family 1 member B10 (AKR1B10) between the KRAS

resultsAKR1B10 was highly expressed in the KRAS

conclusionAKR1B10 facilitated immune evasion of KRAS

Indexed as

Aldo-Keto ReductasesColorectal NeoplasmsHistonesLiver NeoplasmsNeutrophilsProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorFemaleHumansImmune EvasionMiceMutationTumor MicroenvironmentAKR1B10 protein, humanAldo-Keto ReductasesHistonesKRAS protein, humanProto-Oncogene Proteins p21(ras)Colorectal cancer liver metastasisKRASG12C mutationLactylationNeutrophils infiltrationTumor microenvironment

Identifiers

PMID41630031
PMCPMC12955136

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.