Evidence map›Paper›PMID 41629969›Full record

ArticleJournal of nanobiotechnology2026

Metal-ion-coordinated silk fibroin nanogels for enhanced oral chemotherapy of colorectal cancer.

Baoyi Li, Jinhua Liu, Xiaoyan Li, Yuting Luo, Ga Liu, Menghang Zu, Yajun Wang, Xiaoxiao Shi, Rui L Reis, Subhas C Kundu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Baoyi LiDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Jinhua LiuCollege of Sericulture, Textile, and Biomass Sciences, Southwest University, Chongqing, 400715, China.
Xiaoyan LiDepartment of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Yuting LuoDepartment of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Ga LiuDepartment of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Menghang ZuDepartment of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Yajun WangDepartment of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. yajunw24@uestc.edu.cn.
Xiaoxiao ShiCollege of Sericulture, Textile, and Biomass Sciences, Southwest University, Chongqing, 400715, China.
Rui L Reis3Bs Research Group I3Bs - Research Institute on Biomaterials, Biodegradables, and Biomimetics, European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho Headquarters, Barco, 4805-017, Guimarães, Portugal.
Subhas C Kundu3Bs Research Group I3Bs - Research Institute on Biomaterials, Biodegradables, and Biomimetics, European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho Headquarters, Barco, 4805-017, Guimarães, Portugal.
Bo XiaoDepartment of Pharmacy, Personalized Drug Research and Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. bxiao@uestc.edu.cn.
Zhenhua ZhuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China. zhuzhenhua19820122@163.com.

Funding

Fundamental Research Funds for the Central Universities SWU-KQ22075National Natural Science Foundation of China 82360110 and 32401170Natural Science Foundation of Jiangxi Province 20224BAB206073Science and Technology Research Program of Chongqing Municipal Education Commission KJQn202300223
6 · The paper itself

Abstract

The efficacy of oral chemotherapy for colorectal cancer (CRC) is hampered by poor drug stability and absorption in the upper gastrointestinal tract, as well as inadequate targeting efficiency at tumor sites. To address these issues, we proposed a simple and biocompatible nanogel, which was co-assembled from chemotherapeutic drug 5-fluorouracil (5-FU), regenerated silk fibroin (SF) as a natural protein carrier, and metal ions (Ni

Indexed as

Antineoplastic AgentsColorectal NeoplasmsFibroinsFluorouracilNanogelsAdministration, OralAlginatesAnimalsCell Line, TumorChitosanDrug CarriersDrug LiberationHumansHydrogelsMiceTumor MicroenvironmentAlginatesAntineoplastic AgentsChitosanDrug CarriersFibroinsFluorouracilHydrogelsNanogels5-FluorouracilColorectal cancerMetal ionNanogelSilk fibroin

Identifiers

PMID41629969
PMCPMC12955276

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.