Evidence map›Paper›PMID 41629909›Full record

SynthesisMalaria journal2026

Pooled prevalence of Glucose-6-phosphate dehydrogenase deficiency among malaria patients in Ethiopia: a systematic review and meta-analysis.

Gashaw Dessie, Mihret Getnet, Amare Belete Getahun, Tiget Ayelgn Mengstie, Tseganesh Asefa, Engidaw Fentahun Enyew, Thomas Kidanemariam Yewodiaw, Hiwot Tezera Endale, Helen Lamesgin Endalew

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Malaria journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Gashaw DessieDepartment of Medical Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. tiruwork.dessie12@gmail.com.
Mihret GetnetDepartment of Human Physiology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Amare Belete GetahunDepartment of Anesthesia, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Tiget Ayelgn MengstieDepartment of Medical Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Tseganesh AsefaDepartment of Medical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Engidaw Fentahun EnyewDepartment of Human Anatomy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Thomas Kidanemariam YewodiawMedical Officer at International Medical Corps, Amhara Region Emergency Operation Center, Gondar Field Office, Gondar, Ethiopia.
Hiwot Tezera EndaleDepartment of Medical Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Helen Lamesgin EndalewDepartment of Surgical Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria is a major global health burden that accounts for the morbidity and mortality of the population. The 2020 World Health Organization reports showed that malaria affects around 241 million people worldwide. Therefore, the study evaluated the pooled prevalence of Glucose-6-phosphate dehydrogenase deficiency (G6PDd) in patients with malaria.

methodsVarious electronic databases were used to search all relevant studies through consideration of all study periods. The data were collected from PubMed, Cochrane, and Hinari, databases. Additionally, the Google Scholar search engine was used to screen research articles in the study area. The pooled prevalence of G6PDd was determined using a random effects model. On the other hand, sensitivity analysis and publication bias were performed during the meta-analysis.

resultsThe overall pooled prevalence of G6PDd was 6% (0.04-0.08: 95% CI). The highest and lowest prevalence of G6PDd were 23% (0.06-0.41: 95% CI) and 1% (0.00-0.03: 95% CI) estimated at Jimma and three malaria endemic regions respectively.

conclusionsIn this study, the overall pooled prevalence of G6PDd was 6%. The prevalence of emerging mutant variants such as ChrX:154535443, ChrX:6369, ChrX:6504, and G267 + 119C/T has been detected in specific study areas. However, the majority of G6PDd cases were associated with the A376G and A376T mutant variants. The G6PDd G202A was also detected even if its distribution was low compared to these mutants.

Indexed as

Glucosephosphate Dehydrogenase DeficiencyMalariaEthiopiaHumansPrevalenceEthiopiaGlucose-6-phosphate dehydrogenase deficiencyMalariaMeta-analysisPrevalence

Identifiers

PMID41629909
PMCPMC12955299

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.