ArticleMethods in molecular biology (Clifton, N.J.)2026
Laser Capture Microdissection Followed by Histone H1 Variant Analysis by Mass Spectrometry.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The histone H1 family comprises of essential components of chromatin, which bind to the linker DNA connecting individual nucleosomes and contribute to the formation of higher-order chromatin structures. Multiple histone H1 exist, each with distinct interactions with the nucleosome that specifically influence chromatin organization and nuclear functions. Histone H1 variants have been shown to play a role as drivers in cancer and may serve as biomarkers for patient stratification. To overcome the limitations associated with antibody- and RNA-based methods for analyzing histone H1, we developed a mass spectrometry (MS)-based label-free approach to simultaneously analyze all somatic histone H1 variants in patient-derived samples. Here, we describe how this method can be used for the analysis of low-amount clinical samples obtained through laser capture microdissection of tissue sections.
Indexed as
Identifiers
41629714What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.