Evidence map›Paper›PMID 41629684›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Down syndrome birth rate post Dobbs decision: has it changed?

Stephanie L Santoro, Chance Alvarado, Stephanie Y Tseng, Sara Conroy, Isaac Kistler, Stephen A Hart, Samantha Fichtner, Clifford L Cua

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephanie L Santoro *Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4172-0288
Chance Alvarado *Nationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-7266-6344
Stephanie Y TsengNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Sara ConroyNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9155-9456
Isaac KistlerNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0009-0005-4025-1327
Stephen A HartNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-1651-4511
Samantha FichtnerNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
Clifford L CuaNationwide Children's Hospital Heart Center, Nationwide Children's Hospital, Columbus, OH, USA. Clifford.Cua@nationwidechildrens.org.ORCID http://orcid.org/0000-0002-9172-3874

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn 2022, the U.S. Supreme Court decision on Dobbs v. Jackson Women's Health Organization changed abortion access. We evaluated birth rates of Down syndrome (DS) before and after the Dobbs decision hypothesizing similarity to cyanotic congenital heart disease. STUDY

designRetrospective cohort study of live births utilizing 2016 - 2025 CDC birth certificate registry data stratified by DS and by state abortion access categories (restrictive and protective) based on the Guttmacher Institute. Incidence of DS and the difference in incidence between state cohorts were modeled and compared between pre- and post-Dobbs periods using segmented linear regression.

resultsIncidence of DS live births remained stable in restrictive and protective states pre- and post-Dobbs. Segmented regression models revealed no significant changes in monthly incidence in the post-Dobbs era nationally compared to pre-Dobbs.

conclusionsMean monthly incidence of DS in live-born infants using CDC birth certificate data did not increase after the Dobbs decision.

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.