Evidence map›Paper›PMID 41629633›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Stereoselective, sex-dependent 5-HT

Maya C Gaines-Smith, Justin M Silverman, Michael Fiorillo, Jason Younkin, Karah N Moore, Jessica L Maltman, Mario de la Fuente Revenga, Jennifer T Wolstenholme, Richard A Glennon, Małgorzata Dukat and 1 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Psilocybin modulates social behaviour in male and female mice in a time-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maya C Gaines-SmithDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Justin M SilvermanDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Michael FiorilloDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Jason YounkinDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Karah N MooreDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Jessica L MaltmanDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Mario de la Fuente RevengaDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Jennifer T WolstenholmeDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.ORCID http://orcid.org/0000-0003-3812-9312
Richard A GlennonDepartment of Medicinal Chemistry, Virginia Commonwealth University School of Pharmacy, Richmond, VA, USA.
Małgorzata DukatDepartment of Medicinal Chemistry, Virginia Commonwealth University School of Pharmacy, Richmond, VA, USA.
Javier González-MaesoDepartment of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. javier.maeso@vcuhealth.org.ORCID http://orcid.org/0000-0003-3105-3204

Funding

Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MICHAEL F MILES · 2014 to 2026
$19.6M
Structure and function of the 5HT2A/mGluR2 complex in schizophreniaR01MH084894 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Javier Gonzalez-Maeso · 2009 to 2026
$6.8M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Virginia Commonwealth University Initiative for Maximizing Student DevelopmentR25GM090084 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI AKBARALI, HAMID I, LLOYD, JOYCE A. · 2010 to 2022
$5.2M
Virginia Commonwealth University Postbaccalaureate Research Education ProgramR25GM089614 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Rebecca Kelley Martin · 2010 to 2026
$4.9M
NIGMS NIH HHS R25 GM089614NIGMS NIH HHS R25 GM090084NIMH NIH HHS R01 MH084894NIMH NIH HHS T32 MH020030U.S. Department of Health & Human Services | National Institutes of Health (NIH) NIDA T32DA007027U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) P50AA022537Virginia Commonwealth University (VCU) VCU Breakthroughs Fund
6 · The paper itself

Abstract

The psychoactive entactogen 3,4-methylenedioxymethamphetamine (MDMA), widely known as a recreational drug, is gaining renewed attention as a potential psychotherapeutic adjunct for treatment-resistant psychiatric disorders, yet its neurobiological mechanisms - particularly those related to its stereoisomers and sex-specific effects - remain poorly understood. Here, we report stereoselective and sex-dependent actions of MDMA on serotonin (or 5-hydroxytryptamine) 2A receptor (5-HT

Indexed as

Frontal LobeNeuronal PlasticityN-Methyl-3,4-methylenedioxyamphetamineReceptor, Serotonin, 5-HT2ASerotonin AgentsSex CharacteristicsAnimalsDose-Response Relationship, DrugFemaleHEK293 CellsHumansMaleMiceMice, Inbred C57BLSerotonin 5-HT2 Receptor AgonistsStereoisomerismN-Methyl-3,4-methylenedioxyamphetamineReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor AgonistsSerotonin Agents

Identifiers

PMID41629633
PMCPMC13125254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.