Evidence map›Paper›PMID 41629621›Full record

ArticleLeukemia2026

JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms.

David Kealy, Ruth Ellerington, Suraj Bansal, Jessie J F Medeiros, Catherine A Hawley, Andy G X Zeng, Jakub Lukaszonek, Katie A West, Aparna D Sinha, Gillian Caalim and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

David Kealy *Centre for Blood Research, University of York, York, UK.ORCID 0000-0001-9246-8134
Ruth Ellerington *Centre for Blood Research, University of York, York, UK.ORCID 0000-0001-7978-9873
Suraj BansalPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0003-4023-6635
Jessie J F MedeirosPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0001-6597-4613
Catherine A HawleyCentre for Blood Research, University of York, York, UK.
Andy G X ZengPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Jakub LukaszonekCentre for Blood Research, University of York, York, UK.
Katie A WestCentre for Blood Research, University of York, York, UK.
Aparna D SinhaCentre for Blood Research, University of York, York, UK.ORCID 0000-0001-5184-1326
Gillian CaalimCentre for Blood Research, University of York, York, UK.
Richard T GawneYork Biomedical Research Institute, University of York, York, UK.
Jacob PopeYork Biomedical Research Institute, University of York, York, UK.ORCID 0009-0004-8970-0456
Bianca Lima FerreiraCentre for Blood Research, University of York, York, UK.ORCID 0000-0001-7578-2244
Nicole-Mae BlacknellCentre for Blood Research, University of York, York, UK.ORCID 0009-0007-5241-2575
Bryce DrylieCentre for Blood Research, University of York, York, UK.
Jenny ChatzigerouCentre for Blood Research, University of York, York, UK.ORCID 0009-0008-0063-0295
Hwei Minn KhooMedical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.
Adam C WilkinsonUniversity of Cambridge, Cambridge, UK.
Adele K FieldingCentre for Blood Research, University of York, York, UK.ORCID 0000-0002-4746-7789
Guanlin WangMedical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.
Bethan PsailaMedical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM) and NIHR Biomedical Research Centre Haematology Theme, University of Oxford, Oxford, UK.ORCID 0000-0001-8198-9663
David G KentCentre for Blood Research, University of York, York, UK.ORCID 0000-0001-7871-8811
Ian S HitchcockCentre for Blood Research, University of York, York, UK.
Andrew N HoldingYork Biomedical Research Institute, University of York, York, UK.ORCID 0000-0002-8459-7048
Andrew S MasonYork Biomedical Research Institute, University of York, York, UK.ORCID 0000-0002-8222-3974
Vikas GuptaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID 0000-0002-1419-8607
John E DickPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Katherine S BridgeCentre for Blood Research, University of York, York, UK. katherine.bridge@york.ac.uk.ORCID 0000-0003-1516-1459

Funding

Kay Kendall Leukaemia Fund (KKLF) KKL1377RCUK | Medical Research Council (MRC) UKRI1444UKRI Medical Research Council grant MC_PC_21043Wellcome Trust (Wellcome) 302479/Z/23/Z
6 · The paper itself

Abstract

Hypoxia-inducible factors (HIFs) are master transcriptional regulators, central to cellular survival in hypoxia and frequently activated within malignancy. Whilst malignant context directs the role of HIFs within oncogenesis, these mechanisms are not well characterised. Applying the JAK2V617F myeloproliferative neoplasms (MPNs) oncogene-driver model, in which HIF-1α is stabilised in normoxia (20% O

Indexed as

HypoxiaHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitJanus Kinase 2Myeloproliferative DisordersRegulonAnimalsCell HypoxiaHumansMiceProto-Oncogene Proteins c-pim-1HIF1A protein, humanHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitJAK2 protein, humanJanus Kinase 2Proto-Oncogene Proteins c-pim-1

Identifiers

PMID41629621
PMCPMC12960217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.