Evidence map›Paper›PMID 41629567›Full record

ArticleScientific reports2026

The hypoxic tight-skin mouse model of Group 3 pulmonary hypertension.

L Chi, A E Foley, G Goodarzi, A Volchuk, K P B Fuerte, K J Tracey, Y Al-Abed, B E Steinberg, N M Goldenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

L ChiDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
A E FoleyDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
G GoodarziProgram in Cell and Systems Biology, SickKids Research Institute, Toronto, ON, Canada.
A VolchukProgram in Cell and Systems Biology, SickKids Research Institute, Toronto, ON, Canada.
K P B FuerteDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
K J TraceyFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Y Al-AbedFeinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
B E SteinbergDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
N M GoldenbergDepartment of Physiology, University of Toronto, Toronto, ON, Canada. neil.goldenberg@sickkids.ca.

Funding

CIHR PJT180524
6 · The paper itself

Abstract

Pulmonary hypertension (PH) arising from chronic lung disease and hypoxia is a deadly condition without cure. Small animal models using hypoxia are mild, and do not fully recapitulate human disease. The tight skin mouse (Tsk

Indexed as

Hypertension, PulmonaryHypoxiaAnimalsCell ProliferationDisease Models, AnimalFibroblastsHMGB1 ProteinHumansLungMaleMiceMyocytes, Smooth MusclePulmonary ArterySignal TransductionTransforming Growth Factor betaHMGB1 ProteinTransforming Growth Factor betaChronic hypoxiaFibroblastsGroup 3 pulmonary hypertensionHMGB1

Identifiers

PMID41629567
PMCPMC12916770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.