Evidence map›Paper›PMID 41629525›Full record

ArticleCommunications biology2026

Structural mechanism of anti-MHC-I antibody blocking of inhibitory NK cell receptors in tumor immunity.

Jiansheng Jiang, Abir K Panda, Kannan Natarajan, Haotian Lei, Shikha Sharma, Lisa F Boyd, Reanne R Towler, Sruthi Chempati, Javeed Ahmad, Abraham J Morton and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Jiansheng Jiang *Molecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. jiangji@niaid.nih.gov.ORCID http://orcid.org/0000-0003-0964-5481
Abir K Panda *Cellular Immunology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kannan Natarajan *Molecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6295-2571
Haotian LeiResearch Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4882-0249
Shikha SharmaComputational Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Lisa F BoydMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Reanne R TowlerMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0009-0001-7016-716X
Sruthi ChempatiCellular Immunology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Javeed AhmadMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Abraham J MortonLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Zabrina C LangLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Yi SunPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nikolaos SgourakisPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-3655-3902
Martin Meier-SchellersheimComputational Systems Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8754-6377
Rick K HuangLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Ethan M ShevachCellular Immunology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. eshevach@niaid.nih.gov.ORCID http://orcid.org/0000-0003-1607-4664
David H MarguliesMolecular Biology Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. dmargulies@niaid.nih.gov.ORCID http://orcid.org/0000-0001-8530-7375

Funding

Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) ZIA AI000622-34
6 · The paper itself

Abstract

Anti-major histocompatibility complex class I (MHC-I) mAbs can stimulate immune responses to tumors and infections by blocking suppressive signals delivered via various immune inhibitory receptors. To understand such functions, we determined the structure of a highly cross-reactive anti-human MHC-I mAb, B1.23.2, in complex with the MHC-I molecule HLA-B*44:05 by both cryo-electron microscopy (cryo-EM) and X-ray crystallography. Structural models determined by the two methods were essentially identical revealing that B1.23.2 binds a conserved region on the α2

Indexed as

Antibodies, MonoclonalHistocompatibility Antigens Class IKiller Cells, NaturalNeoplasmsPancreatic NeoplasmsReceptors, Natural Killer CellAnimalsCryoelectron MicroscopyCrystallography, X-RayHumansMiceModels, MolecularReceptors, KIRAntibodies, MonoclonalHistocompatibility Antigens Class IReceptors, KIRReceptors, Natural Killer Cell

Identifiers

PMID41629525
PMCPMC12966442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.