Evidence map›Paper›PMID 41629483›Full record

ArticleScientific reports2026

PARP-1 couples β-catenin/TCF4 signaling to epithelial-mesenchymal transition in endometriosis.

Lu Zhang, Xianli Li, Liang Kong, Xiaoying Hou, Bohan Li, Ying Zhang, Jinjuan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lu ZhangDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Xianli LiDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Liang KongDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Xiaoying HouDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Bohan LiDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Ying ZhangDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Jinjuan WangDepartment of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China. wjj2007@mail.ccmu.edu.cn.

Funding

Natural Science Foundation of Beijing Municipality 7222061
6 · The paper itself

Abstract

Endometriosis exhibits epithelial–mesenchymal transition (EMT)-aligned traits that promote invasion and lesion persistence. We investigated whether poly(ADP-ribose) polymerase-1 (PARP-1) coordinates β-catenin/TCF4 activity with EMT programs and whether these features are amenable to pharmacologic inhibition. PARP-1 and EMT markers were profiled in normal endometrium and ovarian endometriotic lesions. In endometriotic epithelial cells, PARP-1 levels were modulated by overexpression or siRNA and effects on EMT markers and motility were quantified. Association of PARP-1 with β-catenin/TCF4 complexes was evaluated, and a lesion model was used to test the impact of PARP inhibition on EMT features and lesion burden. PARP-1 was elevated in ectopic lesions and aligned with EMT-associated marker shifts. PARP-1 gain increased β-catenin/TCF4 activity, remodeled EMT markers, and enhanced motility, whereas PARP-1 loss produced the opposite pattern. Analyses supported PARP-1 association with β-catenin/TCF4 complexes. Pharmacologic PARP inhibition attenuated β-catenin/TCF4-aligned EMT features in vitro and reduced lesion growth with concurrent marker normalization in vivo. These findings indicate that PARP-1 couples Wnt/β-catenin signaling to EMT programs in endometriosis and identify PARP inhibition as a tractable approach to modulate these phenotypes.

Indexed as

beta CateninEndometriosisEpithelial-Mesenchymal TransitionPoly (ADP-Ribose) Polymerase-1Signal TransductionTranscription Factor 4AnimalsCell MovementEpithelial CellsFemaleHumansbeta CateninPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1TCF4 protein, humanTranscription Factor 4EndometriosisEpithelial–mesenchymal transitionPARP inhibitorPoly(ADP-ribose) polymerase 1T-cell factor 4β-catenin

Identifiers

PMID41629483
PMCPMC12917139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.