ArticleInternational journal of obesity (2005)2026
Peak oxygen consumption as a modifier of the obesity paradox in patients with obesity with heart failure with reduced ejection fraction.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundObesity is linked to adverse health effects, but paradoxically improves survival in heart failure (HF). Peak oxygen consumption (VO
methodsWe retrospectively reviewed 18,879 patients who underwent maximal cardiopulmonary exercise testing using the modified Bruce ramp protocol between 2012 and 2020. The inclusion criteria were left ventricular ejection fraction <40% and body mass index (BMI) > 18.5 kg/m
resultsFor the 819 included patients (292 with normal weight, 197 with overweight, 330 with obesity), median age was 59 (interquartile range [IQR]: 49-67) years, 75.2% were male, and the median BMI was 24.1 (IQR: 22.1-26.5) kg/m
conclusionsPatients with obesity and HFrEF showed better survival, consistent with the obesity paradox. However, the U-shaped relationship between peak VO
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