Evidence map›Paper›PMID 41629354›Full record

ArticleNature communications2026

Gut microbiota-derived butyrate primes systemic immunity in honey bees by mediating lipid metabolic reprogramming.

Jiaming Liu, Yashuai Wu, Zhenfang Li, Junbo Tang, Xin Zhou, Shiqi Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiaming LiuState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0001-7571-8760
Yashuai WuState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.ORCID http://orcid.org/0009-0008-3936-289X
Zhenfang LiState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.
Junbo TangState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.
Xin ZhouState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China.ORCID http://orcid.org/0000-0002-1407-7952
Shiqi LuoState Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, Department of Entomology, College of Plant Protection, China Agricultural University, Beijing, China. shiqi_luo@cau.edu.cn.ORCID http://orcid.org/0000-0002-0506-2230

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2023YFD2201804National Natural Science Foundation of China (National Science Foundation of China) 32000343
6 · The paper itself

Abstract

The gut microbiota plays a crucial role in insect immune priming, inducing enhanced immune response that functionally resembles acquired immunity confined to vertebrates. While gut microbiota mediates systemic immune activation in insect hemolymph, the mechanisms underlying remote immunoregulation remain largely unknown. Here we use the honey bee gut microbiota as a model, we identify butyrate as a key microbial metabolite coordinating immune-metabolic crosstalk. Butyrate supplementation restores immune competence in germ-free bees, mirroring the protective effects of microbiota-colonized individuals. Butyrate orchestrates lipid metabolic reprogramming in the fat body by activating glycerolipid and arachidonic acid metabolism through activating the G-protein coupled receptor 41 while inhibiting histone deacetylases. These changes in-turn upregulate prostaglandin E

Indexed as

ButyratesGastrointestinal MicrobiomeLipid MetabolismAnimalsArachidonic AcidBeesDinoprostoneFat BodyHemolymphMetabolic ReprogrammingTrained ImmunityArachidonic AcidButyratesDinoprostone

Identifiers

PMID41629354
PMCPMC13031938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.